PMID- 6453496
OWN - NLM
STAT- MEDLINE
DCOM- 19810723
LR  - 20180216
IS  - 0001-5792 (Print)
IS  - 0001-5792 (Linking)
VI  - 65
IP  - 3
DP  - 1981
TI  - Changes in glucose 6-phosphate dehydrogenase and phosphofructokinase activity 
      during maturation and ageing of red blood cells in children with chronic renal 
      insufficiency.
PG  - 164-9
AB  - Red blood cells (RBC) of children with terminal renal insufficiency show a 
      reduction of the apparent 51Cr RBC half-life (16.5 +/- 5.5 days). The enzymatic 
      activities of phosphofructokinase (PFK) and glucose 6-phosphate dehydrogenase 
      (G6PD) in the RBC of these patients do not differ from those in health persons. 
      The RBC of uraemic and healthy children were separated by density gradient 
      centrifugation in dextran medium according to maturity and age. RET count, mean 
      cellular Hb concentration (MCHC), PFK and G6PD activities were determined in the 
      separated cell populations. MCHC increases with increasing cell density while the 
      number of RET decreases. There is a distinct decrease in the G6PD activity of 
      low-density cells compared to high-density cells. The extent of the decrease in 
      enzymatic activity is about the same for healthy persons as for uraemic patients. 
      A more rapid decrease in G6PD activity per unit of time can be assumed when the 
      enzymatic activity is plotted against the distinctly shortened life span of the 
      RBC of the uraemic children. There is a possible relationship between G6PD 
      activity in old RBC and the premature destruction of these cells. PFK activity 
      apparently does not decrease with increasing cell age.
FAU - Eggert, W
AU  - Eggert W
FAU - Scigalla, P
AU  - Scigalla P
FAU - Gross, J
AU  - Gross J
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Acta Haematol
JT  - Acta haematologica
JID - 0141053
RN  - EC 1.1.1.49 (Glucosephosphate Dehydrogenase)
RN  - EC 2.7.1.11 (Phosphofructokinase-1)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - *Erythrocyte Aging
MH  - Erythrocyte Count
MH  - Erythrocytes/*enzymology
MH  - Glucosephosphate Dehydrogenase/*blood
MH  - Half-Life
MH  - Humans
MH  - Kidney Failure, Chronic/*blood/enzymology
MH  - Phosphofructokinase-1/*blood
EDAT- 1981/01/01 00:00
MHDA- 1981/01/01 00:01
CRDT- 1981/01/01 00:00
PHST- 1981/01/01 00:00 [pubmed]
PHST- 1981/01/01 00:01 [medline]
PHST- 1981/01/01 00:00 [entrez]
AID - 10.1159/000207173 [doi]
PST - ppublish
SO  - Acta Haematol. 1981;65(3):164-9. doi: 10.1159/000207173.