PMID- 6454601
OWN - NLM
STAT- MEDLINE
DCOM- 19810925
LR  - 20190515
IS  - 0012-1797 (Print)
IS  - 0012-1797 (Linking)
VI  - 30
IP  - 8
DP  - 1981 Aug
TI  - Diabetes induced with multiple subdiabetogenic doses of streptozotocin: lack of 
      protection by exogenous superoxide dismutase.
PG  - 634-8
AB  - The addition of exogenous superoxide dismutase (SOD) was examined as a possible 
      means of protecting B-cells of mice against either the immediate or delayed 
      toxicity caused by multiple injections of low doses of streptozotocin (Sz). Three 
      different routes of SOD administration (i.p. and i.v. injection and continuous 
      s.c. infusion) and several different doses and schedules were tried. In addition, 
      a long-acting derivative of SOD was synthesized and tested. Despite the 
      observation of a modest delay in the onset of diabetes in one experiment, no 
      protective effect of SOD on the progressive elevation of blood glucose 
      concentrations was evident in the majority of studies. Moreover, a loss in 
      pancreatic insulin content and a tripling of pancreatic glucagon content occurred 
      in all mice treated with low dosages of Sz, irrespective of whether or not either 
      SOD or a long-acting derivative of SOD was administered. Finally, in parallel 
      experiments in vitro, this enzyme was ineffective in protecting isolated rat 
      islets from the acute toxicity of exposure to Sz on glucose-stimulated insulin 
      release.
FAU - Gold, G
AU  - Gold G
FAU - Manning, M
AU  - Manning M
FAU - Heldt, A
AU  - Heldt A
FAU - Nowlain, R
AU  - Nowlain R
FAU - Pettit, J R
AU  - Pettit JR
FAU - Grodsky, G M
AU  - Grodsky GM
LA  - eng
GR  - AM01410/AM/NIADDK NIH HHS/United States
GR  - AM21933/AM/NIADDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Diabetes
JT  - Diabetes
JID - 0372763
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 5W494URQ81 (Streptozocin)
RN  - 9007-92-5 (Glucagon)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - Animals
MH  - Blood Glucose/*metabolism
MH  - Diabetes Mellitus, Experimental/*blood
MH  - Glucagon/metabolism
MH  - Half-Life
MH  - Insulin/metabolism
MH  - Male
MH  - Mice
MH  - Pancreas/drug effects/metabolism
MH  - Streptozocin/*administration & dosage
MH  - Superoxide Dismutase/administration & dosage/*pharmacology
EDAT- 1981/08/01 00:00
MHDA- 1981/08/01 00:01
CRDT- 1981/08/01 00:00
PHST- 1981/08/01 00:00 [pubmed]
PHST- 1981/08/01 00:01 [medline]
PHST- 1981/08/01 00:00 [entrez]
AID - 10.2337/diab.30.8.634 [doi]
PST - ppublish
SO  - Diabetes. 1981 Aug;30(8):634-8. doi: 10.2337/diab.30.8.634.