PMID- 645726
OWN - NLM
STAT- MEDLINE
DCOM- 19780628
LR  - 20190626
IS  - 0002-9343 (Print)
IS  - 0002-9343 (Linking)
VI  - 64
IP  - 4
DP  - 1978 Apr
TI  - The assessment of immunologic and clinical changes occurring during 
      corticosteroid therapy for allergic bronchopulmonary aspergillosis.
PG  - 599-606
AB  - Twenty-two patients with allergic bronchopulmonary aspergillosis have been 
      treated and evaluated for a period ranging from two months to nine years. Twelve 
      are available for periodic blood sampling. Data are presented suggesting the 
      following: (1) Patients with allergic bronchopulmonary aspergillosis have high 
      initial levels of total serum immunoglobulin E (IgE). These levels are 
      significantly higher in those patients who had not been previously treated with 
      prednisone for the control of asthma. (2) Treatment with alternate day prednisone 
      (0.5 mg/kg given on alternate days) caused clinical and roentgenologic 
      improvement as well as marked decreases in total serum IgE but does not 
      necessarily prevent recurrence of the disease. (3) Total and specific IgE against 
      Aspergillus antigen may increase prior to and during exacerbations of disease. 
      (4) Specific IgG and IgE against Aspergillus antigen are increased in most 
      patients with allergic bronchopulmonary aspergillosis and reflect disease 
      activity as evidenced by x-ray and clinical exacerbations in some cases. (5) 
      Lymphocyte transformation using Aspergillis antigen, as measured by the whole 
      blood technic, is present in patients with allergic bronchopulmonary 
      aspergillosis, but serial changes in lymphocyte transformation do not correlate 
      with disease activity. (6) Precipitin reactions are present in patients with 
      allergic bronchopulmonary aspergillosis, but presence or absence does not reflect 
      disease activity in most cases.
FAU - Rosenberg, M
AU  - Rosenberg M
FAU - Patterson, R
AU  - Patterson R
FAU - Roberts, M
AU  - Roberts M
FAU - Wang, J
AU  - Wang J
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Med
JT  - The American journal of medicine
JID - 0267200
RN  - 0 (Antigens, Fungal)
RN  - 0 (Immunoglobulin A)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - VB0R961HZT (Prednisone)
SB  - IM
MH  - Antigens, Fungal
MH  - Aspergillosis/*drug therapy/immunology
MH  - Aspergillus/immunology
MH  - Bronchial Diseases/*drug therapy/immunology
MH  - Humans
MH  - Hypersensitivity/*drug therapy/immunology
MH  - Immunoglobulin A
MH  - Immunoglobulin E
MH  - Immunoglobulin G
MH  - Immunoglobulin M
MH  - Lung Diseases, Fungal/*drug therapy/immunology
MH  - Lymphocyte Activation
MH  - Precipitin Tests
MH  - Prednisone/*therapeutic use
MH  - Remission, Spontaneous
EDAT- 1978/04/01 00:00
MHDA- 1978/04/01 00:01
CRDT- 1978/04/01 00:00
PHST- 1978/04/01 00:00 [pubmed]
PHST- 1978/04/01 00:01 [medline]
PHST- 1978/04/01 00:00 [entrez]
AID - 0002-9343(78)90579-X [pii]
AID - 10.1016/0002-9343(78)90579-x [doi]
PST - ppublish
SO  - Am J Med. 1978 Apr;64(4):599-606. doi: 10.1016/0002-9343(78)90579-x.