PMID- 6457544
OWN - NLM
STAT- MEDLINE
DCOM- 19811215
LR  - 20161123
IS  - 0003-0805 (Print)
IS  - 0003-0805 (Linking)
VI  - 124
IP  - 4
DP  - 1981 Oct
TI  - Thallium myocardial perfusion scans for the assessment of right ventricular 
      hypertrophy in patients with cystic fibrosis. A comparison with other noninvasive 
      techniques.
PG  - 463-8
AB  - The incidence of right ventricular hypertrophy in 32 patients with cystic 
      fibrosis was studied using thallium 201 (TI-201) myocardial perfusion scans, and 
      compared with other noninvasive techniques including electrocardiography, 
      vectorcardiography, and M-mode echocardiography. The patients (mean age, 17.3 yr; 
      range, 7 to 33) had a wide range of clinical and pulmonary abnormalities (mean 
      Shwachman-Kulczycki score, 66.6). In the total study group, TI-201 scans, like 
      the vectorcardiograms and the M-mode echocardiograms, gave a surprisingly high 
      proportion of positive predictions for right ventricular hypertrophy (RVH) (44%). 
      The correlations with all other noninvasive methods were uniformly poor, so 
      caution must be exercised in using this technique to predict early RVH in order 
      to follow the natural history of cor pulmonale in cystic fibrosis. At the time of 
      the study, 6 patients had clinical evidence of right ventricular failure, and in 
      this disease setting must have had RVH. In 3 patients, RVH was confirmed at 
      autopsy, and it was successfully predicted by TI-201 scans in 5 of the 6 
      patients. The false negative scan may have been due to regional myocardial 
      ischemia secondary to severe right ventricular failure. In contrast, the 
      vectorcardiogram, using Fowler's new criteria, made a successful prediction of 
      RVH in all 6 patients, and the electro cardiogram in only 3. Although the M-mode 
      echocardiogram was abnormal in all patients, it would have predicted RVH (with 
      increased right ventricular anterior wall thickness) in only 1 patient. We 
      concluded that TI-201 myocardial perfusion cans are good at confirming RVH in 
      cases with established right ventricular failure, but have no advantage over 
      vectorcardiographic assessments, which are logistically easier to perform and 
      carry no radiation risks.
FAU - Newth, C J
AU  - Newth CJ
FAU - Corey, M L
AU  - Corey ML
FAU - Fowler, R S
AU  - Fowler RS
FAU - Gilday, D L
AU  - Gilday DL
FAU - Gross, D
AU  - Gross D
FAU - Mitchell, I
AU  - Mitchell I
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Am Rev Respir Dis
JT  - The American review of respiratory disease
JID - 0370523
RN  - 0 (Radioisotopes)
RN  - AD84R52XLF (Thallium)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cardiomegaly/*diagnostic imaging/etiology
MH  - Child
MH  - Cystic Fibrosis/*complications
MH  - Echocardiography
MH  - Electrocardiography
MH  - Female
MH  - Heart/diagnostic imaging
MH  - Humans
MH  - Male
MH  - Pulmonary Heart Disease/etiology
MH  - Radioisotopes
MH  - Radionuclide Imaging
MH  - Risk
MH  - *Thallium
MH  - Vectorcardiography
EDAT- 1981/10/01 00:00
MHDA- 1981/10/01 00:01
CRDT- 1981/10/01 00:00
PHST- 1981/10/01 00:00 [pubmed]
PHST- 1981/10/01 00:01 [medline]
PHST- 1981/10/01 00:00 [entrez]
AID - 10.1164/arrd.1981.124.4.463 [doi]
PST - ppublish
SO  - Am Rev Respir Dis. 1981 Oct;124(4):463-8. doi: 10.1164/arrd.1981.124.4.463.