PMID- 6462369
OWN - NLM
STAT- MEDLINE
DCOM- 19840918
LR  - 20180214
IS  - 0028-3835 (Print)
IS  - 0028-3835 (Linking)
VI  - 39
IP  - 1
DP  - 1984 Jul
TI  - Effect of experimental alterations in serum levels of 5 alpha-androstane-3 
      beta,17 beta-diol on the timing of puberty in the female rat.
PG  - 19-24
AB  - It has been suggested that in the rat, 5 alpha-androstane-3 alpha,17 beta-diol (3 
      alpha-diol) is physiologically involved in restraining the onset of female 
      puberty. To test this hypothesis several experiments were performed. In normal 
      rats, serum levels of 3 alpha-diol decline slightly during the initial phases of 
      puberty and then sharply several hours before the afternoon preovulatory LH surge 
      on the day of first proestrus. Inhibition of 5 alpha-reductase activity with a 
      highly specific inhibitor, 17 beta-N,N-diethylcarbamoyl-4-methyl-4-aza-5 
      alpha-androstane-3-one (4-MA) strikingly depressed both ovarian content and serum 
      levels of 3 alpha-diol, but failed to advance vaginal opening or first ovulation. 
      Administration of different doses of 3 alpha-diol to juvenile rats via Silastic 
      capsules produced a dose-related increase in serum 3 alpha-diol levels. Titers 
      attained ranged from values similar to those of untreated juvenile rats to levels 
      more than 10-fold higher. None of the concentrations, however, inhibited the LH 
      surge and ovulation induced by pregnant mare serum gonadotropin (PMSG). When a 
      similar treatment was administered to normally maturing rats, only the high dose 
      of 3 alpha-diol delayed the age of vaginal opening and of first ovulation. Serum 
      3 alpha-diol levels attained with this dose were markedly higher than those of 
      untreated juvenile rats (1,086 +/- 267 vs. 124 +/- 14 pg/ml, 
      respectively).(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Ojeda, S R
AU  - Ojeda SR
FAU - Katz, K H
AU  - Katz KH
FAU - Costa, M E
AU  - Costa ME
FAU - Advis, J P
AU  - Advis JP
LA  - eng
GR  - HD-09988/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Switzerland
TA  - Neuroendocrinology
JT  - Neuroendocrinology
JID - 0035665
RN  - 0 (5-alpha Reductase Inhibitors)
RN  - 0 (Androstanols)
RN  - 0 (Gonadotropins, Equine)
RN  - 25126-76-5 (Androstane-3,17-diol)
RN  - 9002-67-9 (Luteinizing Hormone)
SB  - IM
MH  - 5-alpha Reductase Inhibitors
MH  - Androstane-3,17-diol/*blood/metabolism/pharmacology
MH  - Androstanols/*blood
MH  - Animals
MH  - Female
MH  - Gonadotropins, Equine/pharmacology
MH  - Luteinizing Hormone/blood
MH  - Ovary/metabolism
MH  - Ovulation/drug effects
MH  - Rats
MH  - *Sexual Maturation/drug effects
MH  - Vagina/physiology
EDAT- 1984/07/01 00:00
MHDA- 1984/07/01 00:01
CRDT- 1984/07/01 00:00
PHST- 1984/07/01 00:00 [pubmed]
PHST- 1984/07/01 00:01 [medline]
PHST- 1984/07/01 00:00 [entrez]
AID - 10.1159/000123949 [doi]
PST - ppublish
SO  - Neuroendocrinology. 1984 Jul;39(1):19-24. doi: 10.1159/000123949.