PMID- 6463100
OWN - NLM
STAT- MEDLINE
DCOM- 19840904
LR  - 20180214
IS  - 0031-7012 (Print)
IS  - 0031-7012 (Linking)
VI  - 29
IP  - 1
DP  - 1984
TI  - Temporal effects of morphine on rat intestinal transit.
PG  - 47-55
AB  - Rat intestinal transit was determined 30, 60, 150 and 270 min after morphine 
      sulfate or saline given either subcutaneously (s.c.), intraduodenally (i.d.) or 
      intracerebroventricularly (i.c.v.). In addition, two popular methods of 
      quantifying the progression of a radioactive marker along the bowel, the 
      intercept and geometric center methods, were compared. Morphine (5 mg/kg) given 
      s.c. and i.d. produced two distinct periods of reduced intestinal transit, an 
      early phase at 30 min and a late phase at 150 min. Neither phase of the response 
      was influenced by transection of the vagus nerve. The late phase was not affected 
      by cannulation of the bile duct but was completely extinguished when animals were 
      treated with saline instead of the ricinoleic acid, a cathartic agent used in the 
      original experimental protocol. Given i.c.v., morphine (30 micrograms, total 
      dose) inhibited intestinal transit 30 and 60 min after administration. The 
      results indicate that the temporal effects of morphine on rat intestinal transit 
      differ after central and peripheral administration, and in animals treated and 
      not treated with a cathartic agent. Both methods of calculating intestinal 
      transit produced similar statistical results.
FAU - Stewart, J J
AU  - Stewart JJ
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Pharmacology
JT  - Pharmacology
JID - 0152016
RN  - 76I7G6D29C (Morphine)
SB  - IM
MH  - Animals
MH  - Bile Ducts/physiology
MH  - Biological Transport/drug effects
MH  - Duodenum
MH  - Injections, Intraventricular
MH  - Injections, Subcutaneous
MH  - Intestine, Small/*drug effects
MH  - Intubation, Gastrointestinal
MH  - Male
MH  - Morphine/administration & dosage/*pharmacology
MH  - Rats
MH  - Vagotomy
EDAT- 1984/01/01 00:00
MHDA- 1984/01/01 00:01
CRDT- 1984/01/01 00:00
PHST- 1984/01/01 00:00 [pubmed]
PHST- 1984/01/01 00:01 [medline]
PHST- 1984/01/01 00:00 [entrez]
AID - 10.1159/000137991 [doi]
PST - ppublish
SO  - Pharmacology. 1984;29(1):47-55. doi: 10.1159/000137991.