PMID- 6467560
OWN - NLM
STAT- MEDLINE
DCOM- 19841019
LR  - 20191023
IS  - 0009-9090 (Print)
IS  - 0009-9090 (Linking)
VI  - 14
IP  - 4
DP  - 1984 Jul
TI  - Prediction of late asthmatic responses to inhaled allergen.
PG  - 379-85
AB  - Relationships between cutaneous and bronchial responses to allergen were examined 
      in nineteen atopic asthmatics. Allergen inhalation tests elicited an isolated 
      early asthmatic response (EAR) in ten subjects and a dual asthmatic response 
      (DAR) in nine subjects. Ragweed IgE RAST, performed with the sera of those 
      patients tested with ragweed antigen, yielded higher values in all but one 
      patient who experienced DAR than any of the patients with EAR. In one patient 
      with annual symptoms in the ragweed season, positive skin tests with ragweed 
      antigen and DAR to inhaled ragweed extracts, the IgE RAST was entirely negative 
      and the serum IgE concentration was low. Dilutions of the allergen used in each 
      individual for inhalation were also used in skin-prick tests. Early cutaneous 
      allergic response (ECAR) mean wheal diameters were obtained at 10 min and late 
      cutaneous allergic response (LCAR) mean diameters at 6-8 hr. Early asthmatic 
      response (EAR) subjects differed modestly from DAR subjects in the relationships 
      between ECAR and LCAR; in the EAR group, a significantly larger wheal diameter (P 
      less than 0.01) was required before an LCAR ensued, however there was some 
      overlap. Once LCAR developed, there was no difference between EAR and DAR groups 
      in the magnitude of the LCAR. There was a trend (not significant) towards a 
      requirement for a higher antigen concentration in the EAR group to elicit an 
      LCAR.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Boulet, L P
AU  - Boulet LP
FAU - Roberts, R S
AU  - Roberts RS
FAU - Dolovich, J
AU  - Dolovich J
FAU - Hargreave, F E
AU  - Hargreave FE
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Clin Allergy
JT  - Clinical allergy
JID - 0311172
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Allergens/*administration & dosage
MH  - Asthma/*immunology
MH  - Bronchial Provocation Tests
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/analysis
MH  - Male
MH  - Middle Aged
MH  - Radioallergosorbent Test
MH  - Skin Tests
MH  - Time Factors
EDAT- 1984/07/01 00:00
MHDA- 1984/07/01 00:01
CRDT- 1984/07/01 00:00
PHST- 1984/07/01 00:00 [pubmed]
PHST- 1984/07/01 00:01 [medline]
PHST- 1984/07/01 00:00 [entrez]
AID - 10.1111/j.1365-2222.1984.tb02219.x [doi]
PST - ppublish
SO  - Clin Allergy. 1984 Jul;14(4):379-85. doi: 10.1111/j.1365-2222.1984.tb02219.x.