PMID- 6467792
OWN - NLM
STAT- MEDLINE
DCOM- 19841016
LR  - 20190511
IS  - 0009-9236 (Print)
IS  - 0009-9236 (Linking)
VI  - 36
IP  - 3
DP  - 1984 Sep
TI  - Serum disopyramide concentrations and suppression of ventricular premature 
      contractions.
PG  - 326-36
AB  - Serum disopyramide determinations and 24-hour Holter monitoring were performed in 
      20 cardiac subjects with ventricular premature contractions (VPCs) after the 
      first, seventeenth, and thirty-seventh doses of disopyramide, 100 mg (10 
      subjects; low-dose group) or 200 mg (10 subjects; high-dose group) every 6 hr for 
      10 days to assess the ability of single- or first-dose data to predict serum 
      disopyramide concentrations at steady state and the relationship between 
      steady-state serum disopyramide concentrations and VPC suppression. Control 
      Holter recordings were made for 48 hr in each subject. There were strong 
      correlations in both groups between data for the AUC over 0 to 6 hr for the first 
      dose (AUC60) and average (C ss) and trough (C min) steady-rate serum disopyramide 
      concentrations after the seventeenth and thirty-seventh doses and the two 
      combined. C ss and C min were related to AUC60 by the following expressions for 
      both dosage groups: C ss = 0.22 AUC60 + 0.90 and C min = 0.20 AUC60 + 0.70. There 
      were good correlations between 6-hr serum disopyramide concentration after the 
      first dose and C ss and C min. There was strong correlation between overall 
      average steady-state serum disopyramide concentration and suppression of VPC 
      frequency. The relationship between VPC suppression and overall average trough 
      serum disopyramide concentration at steady state, on the other hand, was weak.
FAU - Ueda, C T
AU  - Ueda CT
FAU - Dzindzio, B S
AU  - Dzindzio BS
FAU - Vosik, W M
AU  - Vosik WM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Pharmacol Ther
JT  - Clinical pharmacology and therapeutics
JID - 0372741
RN  - GFO928U8MQ (Disopyramide)
SB  - IM
MH  - Administration, Oral
MH  - Adult
MH  - Aged
MH  - Arrhythmias, Cardiac/*drug therapy
MH  - Biological Availability
MH  - Chromatography, Gas
MH  - Disopyramide/blood/metabolism/*therapeutic use
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Half-Life
MH  - Humans
MH  - Kinetics
MH  - Male
MH  - Middle Aged
MH  - Regression Analysis
EDAT- 1984/09/01 00:00
MHDA- 1984/09/01 00:01
CRDT- 1984/09/01 00:00
PHST- 1984/09/01 00:00 [pubmed]
PHST- 1984/09/01 00:01 [medline]
PHST- 1984/09/01 00:00 [entrez]
AID - 0009-9236(84)90115-2 [pii]
AID - 10.1038/clpt.1984.183 [doi]
PST - ppublish
SO  - Clin Pharmacol Ther. 1984 Sep;36(3):326-36. doi: 10.1038/clpt.1984.183.