PMID- 6468625
OWN - NLM
STAT- MEDLINE
DCOM- 19841025
LR  - 20190629
IS  - 0014-4754 (Print)
IS  - 0014-4754 (Linking)
VI  - 40
IP  - 9
DP  - 1984 Sep 15
TI  - Genetic and histological aspects of stomach lesions induced by systemic injection 
      of phenylbutazone in the rat.
PG  - 967-9
AB  - Roman high-avoidance (RHA/Verh) rats, food-deprived (F-D) for 5 days, had higher 
      stomach lesion scores than did F-D Roman low-avoidance (RLA/Verh) rats. F-D 
      RLA/Verh rats which were injected i.p. with phenylbutazone (PBZ) 24 h before 
      examination, however, had higher scores than did PBZ-treated, F-D RHA/Verh rats. 
      Histologically, extensive edema and cellular infiltration (including numerous 
      erythrocytes) were seen below the lesions, in the submucosa, denoting vascular 
      damage. An attenuating influence of food on the ulcerogenic effects of PBZ, which 
      were much more severe in F-D than in fed rats, was also indicated.
FAU - Driscoll, P
AU  - Driscoll P
FAU - Kugler, P
AU  - Kugler P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Switzerland
TA  - Experientia
JT  - Experientia
JID - 0376547
RN  - GN5P7K3T8S (Phenylbutazone)
SB  - IM
MH  - Animals
MH  - Avoidance Learning
MH  - Food Deprivation
MH  - Male
MH  - *Phenylbutazone
MH  - Rats
MH  - Rats, Mutant Strains
MH  - Stomach Ulcer/chemically induced/*genetics/pathology
EDAT- 1984/09/15 00:00
MHDA- 1984/09/15 00:01
CRDT- 1984/09/15 00:00
PHST- 1984/09/15 00:00 [pubmed]
PHST- 1984/09/15 00:01 [medline]
PHST- 1984/09/15 00:00 [entrez]
AID - 10.1007/BF01946462 [doi]
PST - ppublish
SO  - Experientia. 1984 Sep 15;40(9):967-9. doi: 10.1007/BF01946462.