PMID- 6475790
OWN - NLM
STAT- MEDLINE
DCOM- 19840927
LR  - 20190622
IS  - 0002-9149 (Print)
IS  - 0002-9149 (Linking)
VI  - 54
IP  - 6
DP  - 1984 Sep 1
TI  - Thallium-201 accumulation during reperfusion of ischemic myocardium: dependence 
      on regional blood flow rather than viability.
PG  - 659-63
AB  - These experiments in dogs were designed to determine whether the use of thallium 
      201 (TI-201) accumulation in patients during the reperfusion phase after 
      streptokinase lysis of an intracoronary thrombus is a function of coronary blood 
      flow or a function of myocardial viability. The left anterior descending coronary 
      artery was occluded for 60 minutes in open-chest dogs, and the immediate TI-201 
      accumulation and regional blood flow (MBF) using microspheres was measured in 2 
      groups: 10 minutes after reperfusion in 9 dogs (group A) and 24 hours after 
      reperfusion in 6 dogs (group B). There was an 80% or greater reduction in MBF in 
      the subendocardium during ischemia in both groups of dogs, and it was inferred 
      that the subendocardium was destined to become necrotic in group A and had become 
      necrotic in group B dogs. The ratio of TI-201 accumulation to MBF in the tissue 
      that had been ischemic was not significantly different from the ratio in normal 
      tissue despite MBF being in the normal range in group A (n = 7, 2 dogs excluded 
      because of reactive hyperemia) and being markedly decreased in group B. Thus, the 
      immediate TI-201 distribution was related to MBF, and caution is recommended in 
      its use to assess myocardial salvage in the early reperfusion phase after 
      streptokinase lysis of intracoronary thrombi. These data suggest that the 
      intramyocardial accumulation of TI-201 is predominantly a passive process and 
      independent of Na-K ATPase.
FAU - Forman, R
AU  - Forman R
FAU - Kirk, E S
AU  - Kirk ES
LA  - eng
GR  - HL 27107-02/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
RN  - 0 (Radioisotopes)
RN  - AD84R52XLF (Thallium)
RN  - EC 3.4.- (Streptokinase)
SB  - IM
MH  - Animals
MH  - *Coronary Circulation
MH  - Dogs
MH  - Microspheres
MH  - Myocardial Infarction/drug therapy/*metabolism/pathology/physiopathology
MH  - Myocardium/*metabolism/pathology
MH  - Radioisotopes/*metabolism
MH  - Streptokinase/therapeutic use
MH  - Thallium/*metabolism
EDAT- 1984/09/01 00:00
MHDA- 1984/09/01 00:01
CRDT- 1984/09/01 00:00
PHST- 1984/09/01 00:00 [pubmed]
PHST- 1984/09/01 00:01 [medline]
PHST- 1984/09/01 00:00 [entrez]
AID - 0002-9149(84)90268-6 [pii]
AID - 10.1016/0002-9149(84)90268-6 [doi]
PST - ppublish
SO  - Am J Cardiol. 1984 Sep 1;54(6):659-63. doi: 10.1016/0002-9149(84)90268-6.