PMID- 6476182
OWN - NLM
STAT- MEDLINE
DCOM- 19841017
LR  - 20220317
IS  - 0271-7352 (Print)
IS  - 0271-7352 (Linking)
VI  - 6
IP  - 1
DP  - 1984 Jul-Aug
TI  - Immunologic aspects of human endometriosis.
PG  - 33-6
AB  - General and specific immune function were examined in women with endometriosis. 
      Nonspecific parameters included total leukocyte and differential counts, 
      quantitative immunoglobulin (IgG, IgA, and IgM) determinations, total hemolytic 
      complement, C3, C4, mitogen-induced lymphocyte stimulation, and human leukocyte 
      antigen (HLA) typing; no differences were observed when data were compared to 
      age-matched controls without endometriosis. In contrast, the specific immune 
      response T-lymphocyte-mediated cytotoxicity to autologous endometrial cells was 
      significantly reduced (P less than 0.01) in women with endometriosis. When 
      results from patients were analyzed according to clinical severity of 
      endometriosis, even more striking immunologic alterations were delineated. In 
      addition, lymphocyte stimulation responses to autologous endometrial antigen were 
      lower in patients with severe or moderate disease, approaching statistical 
      significance (P = 0.18 and 0.12, respectively). These studies suggest an 
      immunologic basis for development of endometriosis.
FAU - Steele, R W
AU  - Steele RW
FAU - Dmowski, W P
AU  - Dmowski WP
FAU - Marmer, D J
AU  - Marmer DJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Reprod Immunol (1980)
JT  - American journal of reproductive immunology : AJRI : official journal of the 
      American Society for the Immunology of Reproduction and the International 
      Coordination Committee for Immunology of Reproduction
JID - 8111069
RN  - 0 (Autoantigens)
SB  - IM
MH  - Adult
MH  - Autoantigens/immunology
MH  - Cytotoxicity, Immunologic
MH  - Endometriosis/*immunology
MH  - Female
MH  - Humans
MH  - *Immunity, Cellular
MH  - Infertility, Female/immunology
MH  - Lymphocyte Activation
MH  - Pelvic Neoplasms/*immunology
EDAT- 1984/07/01 00:00
MHDA- 1984/07/01 00:01
CRDT- 1984/07/01 00:00
PHST- 1984/07/01 00:00 [pubmed]
PHST- 1984/07/01 00:01 [medline]
PHST- 1984/07/01 00:00 [entrez]
AID - 10.1111/j.1600-0897.1984.tb00106.x [doi]
PST - ppublish
SO  - Am J Reprod Immunol (1980). 1984 Jul-Aug;6(1):33-6. doi: 
      10.1111/j.1600-0897.1984.tb00106.x.