PMID- 6478443
OWN - NLM
STAT- MEDLINE
DCOM- 19841116
LR  - 20190720
IS  - 0304-3835 (Print)
IS  - 0304-3835 (Linking)
VI  - 24
IP  - 2
DP  - 1984 Sep
TI  - DNA single-strand breaks by nitropyrenes and related compounds in Chinese hamster 
      V79 cells.
PG  - 121-7
AB  - The DNA single-strand breaks (SSB) induced by nitropyrenes and related compounds 
      were studied in Chinese hamster V79 cells. 1-Nitropyrene (1-NP), 
      1,6-dinitropyrene (1,6-DNP), 1,8-dinitropyrene (1,8-DNP), 1-nitrosopyrene (1-NOP) 
      and 1-aminopyrene (1-AP) caused DNA-SSB in the cells. 1-NP induced SSB most 
      effectively among the compounds tested, though the mutagenic activity of 1-NP 
      towards mammalian cells has been reported to be negative or marginal. 1-NOP 
      induced SSB less effectively than 1-NP, though 1-NOP is assumed to be the 
      intermediate to the ultimate metabolite. From in vitro experiments, this result 
      could be explained, at least partly, by the detoxicating function of reduced 
      glutathione (GSH) or other sulfhydryl materials.
FAU - Saito, K
AU  - Saito K
FAU - Mita, S
AU  - Mita S
FAU - Kamataki, T
AU  - Kamataki T
FAU - Kato, R
AU  - Kato R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
RN  - 0 (DNA, Single-Stranded)
RN  - 0 (Pyrenes)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Animals
MH  - Cell Line
MH  - Cricetinae
MH  - Cricetulus
MH  - DNA Replication/drug effects
MH  - DNA, Single-Stranded/*metabolism
MH  - Glutathione/metabolism
MH  - Kinetics
MH  - Lung
MH  - Pyrenes/*toxicity
MH  - Structure-Activity Relationship
EDAT- 1984/09/01 00:00
MHDA- 1984/09/01 00:01
CRDT- 1984/09/01 00:00
PHST- 1984/09/01 00:00 [pubmed]
PHST- 1984/09/01 00:01 [medline]
PHST- 1984/09/01 00:00 [entrez]
AID - 0304-3835(84)90127-7 [pii]
AID - 10.1016/0304-3835(84)90127-7 [doi]
PST - ppublish
SO  - Cancer Lett. 1984 Sep;24(2):121-7. doi: 10.1016/0304-3835(84)90127-7.