PMID- 6481428
OWN - NLM
STAT- MEDLINE
DCOM- 19841101
LR  - 20181113
IS  - 0167-594X (Print)
IS  - 0167-594X (Linking)
VI  - 2
IP  - 2
DP  - 1984
TI  - Misonidazole neurotoxicity in rats: Part I. Evaluation of misonidazole 
      neurotoxicity in rats by analysis of brain stem auditory and cortical evoked 
      potentials.
PG  - 91-4
AB  - The effects of misonidazole (MISO) on brain stem evoked potentials (BAEPs) and 
      cortical evoked potentials (CEPs) were evaluated in 16 Sprague-Dawley rats 
      treated with the agent. As found in previous studies, serial BAEP values were 
      diagnostic of the onset of MISO toxicity before clinical signs and symptoms 
      appeared. However, MISO had no effects on CEPs, which remained essentially 
      unchanged through the course of the experiment. At histologic examination, 
      significant changes were found in the area of the brain stem, but there was no 
      histologic evidence of damage to cortical or subcortical structures caused by 
      MISO administration. The results of this study suggest that the neurotoxic 
      effects of MISO are species-specific, and that while the rat model may be useful 
      for comparison of the relative toxic effects of nitroimidazole radiosensitizers, 
      it is not a model suited for measurement of neurotoxicity caused by MISO in 
      humans and nonhuman primates.
FAU - Edwards, M S
AU  - Edwards MS
FAU - Gordon, D G
AU  - Gordon DG
FAU - Levin, V A
AU  - Levin VA
FAU - Phillips, T L
AU  - Phillips TL
LA  - eng
GR  - CA-13525/CA/NCI NIH HHS/United States
GR  - CA-29748-03/CA/NCI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurooncol
JT  - Journal of neuro-oncology
JID - 8309335
RN  - 0 (Nitroimidazoles)
RN  - 8FE7LTN8XE (Misonidazole)
SB  - IM
MH  - Animals
MH  - Auditory Cortex/pathology
MH  - Brain Diseases/*chemically induced/pathology
MH  - Brain Stem/drug effects/pathology
MH  - Cerebral Cortex/drug effects
MH  - Evoked Potentials, Auditory/drug effects
MH  - Male
MH  - Misonidazole/*toxicity
MH  - Nitroimidazoles/*toxicity
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Reaction Time/drug effects
EDAT- 1984/01/01 00:00
MHDA- 1984/01/01 00:01
CRDT- 1984/01/01 00:00
PHST- 1984/01/01 00:00 [pubmed]
PHST- 1984/01/01 00:01 [medline]
PHST- 1984/01/01 00:00 [entrez]
PST - ppublish
SO  - J Neurooncol. 1984;2(2):91-4.