PMID- 6483941
OWN - NLM
STAT- MEDLINE
DCOM- 19841115
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 21
IP  - 2
DP  - 1984 Aug
TI  - Metronidazole influences the development of neural tolerance to ethanol.
PG  - 317-9
AB  - The duration of the loss of the righting reflex (LoRR) was measured in Swiss 
      Webster (SW) and DBA/2 mice following intraperitoneal injection of ethanol or 
      metronidazole alone or together. A single injection of ethanol induced to short 
      LoRR in SW mice and a long LoRR in DBA/2 mice. Metronidazole did not induce LoRR 
      in either strain. When the mice were exposed daily to ethanol for five days, the 
      duration of the LoRR was prolonged in SW mice and shortened in DBA/2 mice. This 
      indicates the development of increased neural sensitivity to ethanol in SW mice 
      and of neural tolerance to ethanol in DBA/2 mice. The response in SW mice to 
      administration of ethanol and metronidazole together did not differ from their 
      response to ethanol alone. However, the duration of the LoRR in DBA/2 mice 
      injected repeatedly with the two drugs was longer than that observed with ethanol 
      alone. Thus metronidazole appears to inhibit the development of neural tolerance 
      to ethanol in DBA/2 mice but has no effect on ethanol induced LoRR in SW mice.
FAU - Giknis, M L
AU  - Giknis ML
FAU - Damjanov, I
AU  - Damjanov I
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 140QMO216E (Metronidazole)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Animals
MH  - Drug Interactions
MH  - Drug Tolerance
MH  - Ethanol/blood/*pharmacology
MH  - Female
MH  - Metronidazole/*pharmacology
MH  - Mice
MH  - Mice, Inbred DBA
MH  - Postural Balance/drug effects
MH  - Reflex/drug effects
MH  - Sleep/drug effects
EDAT- 1984/08/01 00:00
MHDA- 1984/08/01 00:01
CRDT- 1984/08/01 00:00
PHST- 1984/08/01 00:00 [pubmed]
PHST- 1984/08/01 00:01 [medline]
PHST- 1984/08/01 00:00 [entrez]
AID - 0091-3057(84)90232-6 [pii]
AID - 10.1016/0091-3057(84)90232-6 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1984 Aug;21(2):317-9. doi: 10.1016/0091-3057(84)90232-6.