PMID- 6485008
OWN - NLM
STAT- MEDLINE
DCOM- 19841101
LR  - 20190819
IS  - 0378-4274 (Print)
IS  - 0378-4274 (Linking)
VI  - 22
IP  - 3
DP  - 1984 Sep
TI  - Chronic effects of perchloroethylene on the composition of lipid and acyl groups 
      in cerebral cortex and hippocampus of the gerbil.
PG  - 343-9
AB  - Continuous exposure of Mongolian gerbils to perchloroethylene (PCE) (120 ppm) for 
      12 months in an inhalation chamber caused no changes in body or brain weights. 
      The protein content, the concentration of lipid phosphorus or cholesterol were 
      unaltered in the cerebral cortex and hippocampus. However, a small change in the 
      fatty acid pattern of phospholipid was observed. In the phosphatidylethanolamine 
      of cerebral cortex and hippocampus a decrease was found among the long-chain, 
      linolenic acid-derived, fatty acids. The ratio 22:4 (N-6)/22:5 (N-3) was 
      increased, indicating a shift towards the corresponding linoleic acid-derived 
      22-carbon fatty acids. The observed changes among poly-unsaturated fatty acids 
      are similar to those appearing after peroxidation and either protein or essential 
      fatty acid malnutrition. However, an attractive explanation for the changes is 
      that they represent a response to the fluidizing properties of PCE.
FAU - Kyrklund, T
AU  - Kyrklund T
FAU - Alling, C
AU  - Alling C
FAU - Kjellstrand, P
AU  - Kjellstrand P
FAU - Haglid, K G
AU  - Haglid KG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Toxicol Lett
JT  - Toxicology letters
JID - 7709027
RN  - 0 (Fatty Acids)
RN  - 0 (Membrane Lipids)
RN  - TJ904HH8SN (Tetrachloroethylene)
SB  - IM
MH  - Animals
MH  - Cerebral Cortex/*analysis
MH  - Fatty Acids/*analysis
MH  - Gerbillinae
MH  - Hippocampus/*analysis
MH  - Male
MH  - Membrane Lipids/*analysis
MH  - Tetrachloroethylene/*toxicity
EDAT- 1984/09/01 00:00
MHDA- 1984/09/01 00:01
CRDT- 1984/09/01 00:00
PHST- 1984/09/01 00:00 [pubmed]
PHST- 1984/09/01 00:01 [medline]
PHST- 1984/09/01 00:00 [entrez]
AID - 0378-4274(84)90112-7 [pii]
AID - 10.1016/0378-4274(84)90112-7 [doi]
PST - ppublish
SO  - Toxicol Lett. 1984 Sep;22(3):343-9. doi: 10.1016/0378-4274(84)90112-7.