PMID- 64860
OWN - NLM
STAT- MEDLINE
DCOM- 19770331
LR  - 20190610
IS  - 0140-6736 (Print)
IS  - 0140-6736 (Linking)
VI  - 1
IP  - 8007
DP  - 1977 Feb 12
TI  - Specific and sensitive determination of pregnancy-specific beta 1-glycoprotein by 
      radioimmunoassay. A new pregnancy test.
PG  - 333-5
AB  - A specific and highly sensitive radioimmunoassay (R.I.A.) for determination of 
      pregnancy-specific beta 1-glycoprotein (S.P.1) in human plasma, urine, amniotic 
      fluid, and breast milk has been developed. The minimum detection limit of S.P.1 
      was 8 mug/1 of sample. The assay was applied to plasma and/or urine samples from 
      8 women in early pregnancy. S.P. 1 was detected in the plasma of all three women 
      obtained within 14 days of ovulation, the earliest positive result being at 7 
      days. In another woman plasma was negative at day 18 and positive by day 22. In 
      the three remaining women plasma S.P.1 was detected when measured within 24 to 36 
      days of ovulation. S.P.1 was detected in four urine samples obtained between 20 
      and 28 days after ovulation. S.P.1 was also measured in breast milk, amniotic 
      fluid, cord blood, and plasma of women with ectopic gestation and trophoblastic 
      disease. It is suggested that the assay of S.P.1 may have important advantages 
      over existing systems for detection and monitoring of early pregnancy.
FAU - Grudzinskas, J G
AU  - Grudzinskas JG
FAU - Gordon, Y B
AU  - Gordon YB
FAU - Jeffrey, D
AU  - Jeffrey D
FAU - Chard, T
AU  - Chard T
LA  - eng
PT  - Journal Article
PL  - England
TA  - Lancet
JT  - Lancet (London, England)
JID - 2985213R
RN  - 0 (Blood Proteins)
RN  - 0 (Glycoproteins)
SB  - IM
MH  - Amniotic Fluid/analysis
MH  - Blood Proteins/analysis
MH  - Evaluation Studies as Topic
MH  - Female
MH  - Glycoproteins/*analysis/blood/urine
MH  - Humans
MH  - Milk, Human/analysis
MH  - Pregnancy
MH  - Pregnancy Tests/*methods
MH  - Proteinuria/diagnosis
MH  - Radioimmunoassay/*methods
MH  - Time Factors
EDAT- 1977/02/12 00:00
MHDA- 1977/02/12 00:01
CRDT- 1977/02/12 00:00
PHST- 1977/02/12 00:00 [pubmed]
PHST- 1977/02/12 00:01 [medline]
PHST- 1977/02/12 00:00 [entrez]
AID - S0140-6736(77)91136-9 [pii]
AID - 10.1016/s0140-6736(77)91136-9 [doi]
PST - ppublish
SO  - Lancet. 1977 Feb 12;1(8007):333-5. doi: 10.1016/s0140-6736(77)91136-9.