PMID- 6496872
OWN - NLM
STAT- MEDLINE
DCOM- 19841214
LR  - 20190908
IS  - 0387-7604 (Print)
IS  - 0387-7604 (Linking)
VI  - 6
IP  - 4
DP  - 1984
TI  - Caffeine and its dimethylxanthines and fetal cerebral development in rat.
PG  - 355-61
AB  - The relationship between the distribution and pharmacokinetic behavior of 
      caffeine and its dimethylxanthines in pregnant rats and fetuses and fetal 
      cerebral development was compared in four groups with different modes of oral 
      caffeine ingestion by the mothers. During the premating period and pregnancy, 
      female Wistar rats were divided into 0.04% caffeine (C) and water (W) groups, 
      respectively. When the groups are expressed as W or C before mating-W or C during 
      pregnancy, the fetal body weight was low in the three caffeine-treated groups 
      (W-C, C-W and C-C) and the fetal cerebral weight was the lowest in the W-C group. 
      The mean concentration of caffeine or metabolites in maternal plasma, maternal 
      liver, placenta and fetal cerebrum on gestational day (g d) 21 was increased in 
      the W-C group compared to in the C-C group. The concentration of caffeine in 
      fetal cerebrum was increased but that of metabolites was not, compared to the 
      concentration of caffeine or metabolites in the placenta. Radioactivity in fetal 
      cerebrum after intraperitoneal injection of 14C-caffeine was higher in the W-C 
      group than in the other three groups. After intravenous injection of caffeine the 
      apparent volume of distribution of caffeine in maternal plasma was markedly 
      decreased in the W-C group, and the plasma molar concentration ratio of 
      theophylline to caffeine was significantly increased in both the W-C and C-C 
      groups. The adverse effect of maternal caffeine ingestion on the fetal cerebrum 
      may be associated with the decreased apparent volume of distribution of caffeine 
      in maternal plasma and the high caffeine content of fetal cerebrum.
FAU - Tanaka, H
AU  - Tanaka H
FAU - Nakazawa, K
AU  - Nakazawa K
FAU - Arima, M
AU  - Arima M
FAU - Iwasaki, S
AU  - Iwasaki S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Dev
JT  - Brain & development
JID - 7909235
RN  - 0 (Xanthines)
RN  - 3G6A5W338E (Caffeine)
RN  - C137DTR5RG (Theophylline)
RN  - OBD445WZ5P (Theobromine)
RN  - Q3565Y41V7 (1,7-dimethylxanthine)
SB  - IM
MH  - Abnormalities, Drug-Induced/etiology
MH  - Animals
MH  - Brain/metabolism
MH  - Caffeine/*metabolism
MH  - Female
MH  - Fetus/*metabolism
MH  - *Maternal-Fetal Exchange
MH  - Pregnancy
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Theobromine/metabolism
MH  - Theophylline/metabolism
MH  - Xanthines/*metabolism
EDAT- 1984/01/01 00:00
MHDA- 1984/01/01 00:01
CRDT- 1984/01/01 00:00
PHST- 1984/01/01 00:00 [pubmed]
PHST- 1984/01/01 00:01 [medline]
PHST- 1984/01/01 00:00 [entrez]
AID - S0387-7604(84)80111-4 [pii]
AID - 10.1016/s0387-7604(84)80111-4 [doi]
PST - ppublish
SO  - Brain Dev. 1984;6(4):355-61. doi: 10.1016/s0387-7604(84)80111-4.