PMID- 6498570
OWN - NLM
STAT- MEDLINE
DCOM- 19850103
LR  - 20190904
IS  - 0008-2856 (Print)
IS  - 0008-2856 (Linking)
VI  - 31
IP  - 5
DP  - 1984 Sep
TI  - Isolated regional perfusion; anaesthetic technique, monitoring and blood 
      replacement.
PG  - 552-8
AB  - Isolated regional perfusion for the treatment of malignant melanoma is an 
      accepted method of treatment. No standard of anaesthetic practice has been 
      established for those individuals. Perioperative records of patients undergoing 
      isolated limb perfusion were studied to determine adequate blood replacement. 
      Records were examined and compared for (1) age, (2) ASA physical status, (3) 
      presence of associated disease, (4) anaesthetic technique, (5) the amount of 
      blood and fluid replacement, (6) preoperative haemoglobin (hgb) and haematocrit 
      (hct) and postoperative serial complete blood counts. Fifteen patients were 
      studied (mean age 53 +/- 16 yrs). Mean blood and fluid replacement was: packed 
      red blood cells; 2.28 +/- 0.82 units, 722 +/- 17 ml of 5 per cent albumin, 1747 
      +/- 21 ml crystalloid. There were twelve Physical Status Class I or II and three 
      Class III patients. All patients received general anaesthesia. There was a 
      statistically significant difference in the preoperative and postoperative values 
      for haemoglobin and haematocrit (p less than 0.01) with no difference between the 
      postoperative and discharge values. Adequate blood replacement was determined by 
      the equation: (Formula: see text) Extensive invasive monitoring is not routinely 
      required for adequate blood replacement or the detection of leaks between the 
      systemic and isolated circulation.
FAU - Goldberg, M E
AU  - Goldberg ME
FAU - Rosenblum, H M
AU  - Rosenblum HM
FAU - Seltzer, J L
AU  - Seltzer JL
FAU - Rosato, F E
AU  - Rosato FE
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can Anaesth Soc J
JT  - Canadian Anaesthetists' Society journal
JID - 0371163
RN  - Q41OR9510P (Melphalan)
SB  - IM
MH  - Adult
MH  - Anesthesia, General/*methods
MH  - *Chemotherapy, Cancer, Regional Perfusion
MH  - Hemodynamics/drug effects
MH  - Humans
MH  - Melanoma/*drug therapy
MH  - Melphalan/*therapeutic use
MH  - Middle Aged
MH  - Skin Neoplasms/*drug therapy
EDAT- 1984/09/01 00:00
MHDA- 1984/09/01 00:01
CRDT- 1984/09/01 00:00
PHST- 1984/09/01 00:00 [pubmed]
PHST- 1984/09/01 00:01 [medline]
PHST- 1984/09/01 00:00 [entrez]
AID - 10.1007/BF03009542 [doi]
PST - ppublish
SO  - Can Anaesth Soc J. 1984 Sep;31(5):552-8. doi: 10.1007/BF03009542.