PMID- 6499289
OWN - NLM
STAT- MEDLINE
DCOM- 19850122
LR  - 20190511
IS  - 0160-9289 (Print)
IS  - 0160-9289 (Linking)
VI  - 7
IP  - 11
DP  - 1984 Nov
TI  - Echocardiographic evaluation of cardiovascular effects of amrinone.
PG  - 593-8
AB  - Amrinone, a new inotropic drug, was infused at a dosage of 2.5 mg/kg body weight 
      in 14 patients affected by dilatative cardiomyopathy in New York Heart 
      Association (NYHA) functional class III and IV. Cardiac index, mean arterial 
      pressure, and some echocardiographic parameters were evaluated. Cardiac index 
      (CI) increased from 2.03 +/- 0.24 to 2.82 +/- 0.43 1/min/m2 (p less than 0.001). 
      Fractional shortening (FS) increased from 16.4 +/- 5.2 to 21.5 +/- 5.3% (p less 
      than 0.05). End-diastolic and end-systolic diameters showed a significant 
      reduction. Mean arterial pressure decreased from 90.7 +/- 88 to 87.3 +/- 8.4 mmHg 
      (p less than 0.001), the end-systolic stress (ESS) decreased from 5.8 +/- 1 to 
      5.2 +/- 1 g/cm (p less than 0.001). Analyzing the relationship between FS and 
      ESS, it was possible in some cases to suppose the presence of an important 
      vasodilator effect of the drug. The afterload in 7 patients was therefore 
      modified before and after infusion of the drug to analyze FS at the same levels 
      of afterload. This was done to evaluate the vasodilator effect of amrinone. 
      Examining the regression line of FS/ESS ratio it was possible to observe a 
      predominant vasodilator effect in some patients, but in most, a sinergic action 
      was noted. This may be useful for chronic treatment of congestive heart failure, 
      reducing amrinone doses, and using it in association with other vasodilator 
      drugs.
FAU - Modena, M G
AU  - Modena MG
FAU - Benassi, A
AU  - Benassi A
FAU - Mattioli, G
AU  - Mattioli G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Cardiol
JT  - Clinical cardiology
JID - 7903272
RN  - 0 (Aminopyridines)
RN  - 0 (Cardiotonic Agents)
RN  - JUT23379TN (Amrinone)
SB  - IM
MH  - Adult
MH  - Aminopyridines/*therapeutic use
MH  - Amrinone
MH  - Cardiac Catheterization
MH  - Cardiomyopathy, Dilated/*drug therapy
MH  - Cardiotonic Agents/*therapeutic use
MH  - Echocardiography/*methods
MH  - Female
MH  - Heart Failure/*drug therapy
MH  - Hemodynamics/drug effects
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Contraction/*drug effects
EDAT- 1984/11/01 00:00
MHDA- 1984/11/01 00:01
CRDT- 1984/11/01 00:00
PHST- 1984/11/01 00:00 [pubmed]
PHST- 1984/11/01 00:01 [medline]
PHST- 1984/11/01 00:00 [entrez]
AID - 10.1002/clc.4960071107 [doi]
PST - ppublish
SO  - Clin Cardiol. 1984 Nov;7(11):593-8. doi: 10.1002/clc.4960071107.