PMID- 6500673
OWN - NLM
STAT- MEDLINE
DCOM- 19841231
LR  - 20190722
IS  - 0194-911X (Print)
IS  - 0194-911X (Linking)
VI  - 6
IP  - 5
DP  - 1984 Sep-Oct
TI  - Chronic angiotensin II infusion decreases renal norepinephrine overflow in 
      conscious dogs.
PG  - 675-81
AB  - Sympathetic nerve activity and in particular renal sympathetic nerve activity 
      were monitored in six conscious dogs subjected to 6 days of intravenous 
      angiotensin (ANG II) infusion (20 ng/kg/min). This was accomplished by 
      measurement of both arterial and renal venous plasma catecholamine concentration. 
      During the initial 4 hours of ANG II infusion, mean arterial pressure (MAP) 
      increased 35 +/- 8 mm Hg from a control value of 101 +/- 4 mm Hg. Although there 
      were no significant changes in arterial plasma norepinephrine (NE) concentration 
      at this time (control = 148 +/- 40 pg/ml), arterial plasma epinephrine (E) 
      concentration increased threefold (control 42 +/- 15 pg/ml). After 24 hours of 
      ANG II infusion, MAP remained elevated (132 +/- 5 mm Hg), but plasma E 
      concentration returned to control levels. From Days 2 through 6 of ANG II 
      infusion, MAP was elevated approximately 40 mm Hg, but there were no chronic 
      increases in either arterial plasma E or NE concentrations. In contrast to 
      arterial plasma catecholamine concentration, renal vein plasma NE concentration 
      (control = 216 +/- 27 pg/ml) actually decreased during both the acute (122 +/- 12 
      pg/ml) and chronic (103 +/- 26 pg/ml) phases of ANG II infusion. Moreover, renal 
      NE overflow (renal venous plasma NE concentration-arterial plasma NE 
      concentration X effective renal plasma flow), an index of renal sympathetic nerve 
      activity, was depressed during the chronic phase of ANG II hypertension. These 
      results, therefore, do not support the contention that the sympathetic nervous 
      system mediates the hypertension produced by elevated plasma levels of ANG 
      II.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Carroll, R G
AU  - Carroll RG
FAU - Lohmeier, T E
AU  - Lohmeier TE
FAU - Brown, A J
AU  - Brown AJ
LA  - eng
GR  - HL 06341/HL/NHLBI NIH HHS/United States
GR  - HL 11678/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Hypertension
JT  - Hypertension (Dallas, Tex. : 1979)
JID - 7906255
RN  - 0 (Electrolytes)
RN  - 11128-99-7 (Angiotensin II)
RN  - 4964P6T9RB (Aldosterone)
RN  - X4W3ENH1CV (Norepinephrine)
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - Adrenal Glands/metabolism
MH  - Aldosterone/blood
MH  - Angiotensin II/*pharmacology
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - Dogs
MH  - Electrolytes/metabolism
MH  - Epinephrine/metabolism
MH  - Kidney/innervation/*metabolism
MH  - Male
MH  - Norepinephrine/*metabolism
MH  - Sympathetic Nervous System/drug effects
EDAT- 1984/09/01 00:00
MHDA- 1984/09/01 00:01
CRDT- 1984/09/01 00:00
PHST- 1984/09/01 00:00 [pubmed]
PHST- 1984/09/01 00:01 [medline]
PHST- 1984/09/01 00:00 [entrez]
AID - 10.1161/01.hyp.6.5.675 [doi]
PST - ppublish
SO  - Hypertension. 1984 Sep-Oct;6(5):675-81. doi: 10.1161/01.hyp.6.5.675.