PMID- 6505051
OWN - NLM
STAT- MEDLINE
DCOM- 19850103
LR  - 20190712
IS  - 0031-9384 (Print)
IS  - 0031-9384 (Linking)
VI  - 33
IP  - 1
DP  - 1984 Jul
TI  - Dihydrotestosterone stimulates mounting behavior but not lordosis in female rats.
PG  - 49-53
AB  - The ability of androgens to stimulate masculine sexual behavior is thought to 
      depend on the aromatization of such androgens to estrogens. In this scheme, 
      reduced androgens such as dihydrotestosterone (DHT) which cannot be aromatized, 
      are thought to exert major peripheral but little or no central nervous system 
      influences on the display of masculine sexual behavior. Further, an early report 
      that DHT can induce lordosis, an estrogen (E) dependent behavior, led to a notion 
      that DHT may effect behavior through metabolic intermediates such as 5 
      alpha-androstane-3 beta, 17 beta-diol (ADIOL) which then binds to estrogen 
      receptors eliciting the E-dependent lordotic response. The present study 
      reexamined and compared the relative effectiveness of a range of DHT dosages in 
      stimulating a characteristic masculine (mounting) and feminine (lordosis) sexual 
      behavior. Adult ovariectomized rats were randomly assigned to either 250 
      micrograms or 1 mg daily injections of DHT or DHTP. Other animals received OIL 
      injections or crystalline DHT delivered by two different lengths (20 mm or 40 mm) 
      of Silastic capsules. Animals were tested once weekly (for 5 weeks) for mounting 
      behavior (20 minute test). Then animals were tested thrice (once weekly) for 
      lordosis 4 hrs after the addition of 500 micrograms Progesterone (P). Finally, 
      all females were tested for lordotic potential to respond to 10 micrograms EB 
      plus P. 1 mg DHT or DHTP dosages and the 40 mm-Silastic condition significantly 
      increased mounting behavior over that of lower dosages and OIL controls. A 
      significant correlation existed between mounting frequency and circulating level 
      of serum DHT. Treatment with DHTP was not different than DHT in eliciting 
      mounting behavior.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Gladue, B A
AU  - Gladue BA
LA  - eng
GR  - MH-14621/MH/NIMH NIH HHS/United States
GR  - RR-05836-03/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Receptors, Androgen)
RN  - 0 (Receptors, Estrogen)
RN  - 08J2K08A3Y (Dihydrotestosterone)
SB  - IM
MH  - Animals
MH  - Copulation
MH  - Dihydrotestosterone/blood/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Rats
MH  - Receptors, Androgen/drug effects
MH  - Receptors, Estrogen/drug effects
MH  - Sexual Behavior, Animal/*drug effects
EDAT- 1984/07/01 00:00
MHDA- 1984/07/01 00:01
CRDT- 1984/07/01 00:00
PHST- 1984/07/01 00:00 [pubmed]
PHST- 1984/07/01 00:01 [medline]
PHST- 1984/07/01 00:00 [entrez]
AID - 0031-9384(84)90012-X [pii]
AID - 10.1016/0031-9384(84)90012-x [doi]
PST - ppublish
SO  - Physiol Behav. 1984 Jul;33(1):49-53. doi: 10.1016/0031-9384(84)90012-x.