PMID- 6509781
OWN - NLM
STAT- MEDLINE
DCOM- 19850215
LR  - 20190813
IS  - 0300-0664 (Print)
IS  - 0300-0664 (Linking)
VI  - 21
IP  - 4
DP  - 1984 Oct
TI  - Effect of 'physiological' doses of triiodothyronine replacement on the hormonal 
      and metabolic adaptation to short-term semistarvation and to low-calorie diet in 
      obese patients.
PG  - 357-67
AB  - In four groups of obese patients matched for Body Mass Index (BMI), we studied 
      the effects of different 3-week semi-starvation treatments followed by an 8-week 
      hypocaloric (1008 kcal, protein 20%, carbohydrate 40%) diet with or without low 
      doses of T3 therapy. Dietary intake (formula diet) in the semi-starvation period 
      was 480 kcal, with 66 g protein (P) and 51 g carbohydrate (CHO) in groups I and 
      III and with 33 g P and 84 g CHO in groups II and IV. Moreover, groups III and IV 
      were given low doses (20 micrograms twice a day) of T3 while groups I and II 
      received a placebo. During semi-starvation periods, a similar fall in BMI values 
      was found in all groups, while during the low-calorie diet, T3-treated patients 
      showed the greater BMI reduction. During semi-starvation, nitrogen balance was 
      significantly more negative in low-protein than in high-protein-treated groups; 
      differences between T3-treated (III and IV) and control (I and II) groups were 
      not significant over this relatively short treatment period. No differences in 24 
      h urinary 3-methylhistidine or alanine excretion were evident between the four 
      groups. During the entire period of study, daily urine creatinine excretion did 
      not change in any group. In conclusion, in our study low-dose T3 therapy was seen 
      to favour weight loss during low-calorie diet although negative effects on 
      protein metabolism were not excluded, particularly when relatively small amounts 
      of protein were administered.
FAU - Pasquali, R
AU  - Pasquali R
FAU - Baraldi, G
AU  - Baraldi G
FAU - Biso, P
AU  - Biso P
FAU - Piazzi, S
AU  - Piazzi S
FAU - Patrono, D
AU  - Patrono D
FAU - Capelli, M
AU  - Capelli M
FAU - Melchionda, N
AU  - Melchionda N
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Endocrinol (Oxf)
JT  - Clinical endocrinology
JID - 0346653
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Proteins)
RN  - 0 (Muscle Proteins)
RN  - 0 (Thyroid Hormones)
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - 9002-71-5 (Thyrotropin)
RN  - N762921K75 (Nitrogen)
SB  - IM
MH  - Adult
MH  - Combined Modality Therapy
MH  - Dietary Carbohydrates/administration & dosage
MH  - Dietary Proteins/administration & dosage
MH  - Energy Intake
MH  - Female
MH  - Humans
MH  - Male
MH  - Muscle Proteins/metabolism
MH  - Nitrogen/metabolism
MH  - Obesity/diet therapy/*drug therapy/metabolism
MH  - *Starvation
MH  - Thyroid Hormones/blood
MH  - Thyrotropin/blood
MH  - Triiodothyronine/*administration & dosage/therapeutic use
EDAT- 1984/10/01 00:00
MHDA- 1984/10/01 00:01
CRDT- 1984/10/01 00:00
PHST- 1984/10/01 00:00 [pubmed]
PHST- 1984/10/01 00:01 [medline]
PHST- 1984/10/01 00:00 [entrez]
AID - 10.1111/j.1365-2265.1984.tb03222.x [doi]
PST - ppublish
SO  - Clin Endocrinol (Oxf). 1984 Oct;21(4):357-67. doi: 
      10.1111/j.1365-2265.1984.tb03222.x.