PMID- 6510639
OWN - NLM
STAT- MEDLINE
DCOM- 19850204
LR  - 20141003
IS  - 0016-450X (Print)
IS  - 0016-450X (Linking)
VI  - 75
IP  - 10
DP  - 1984 Oct
TI  - Antitumor activity and toxicity of methyl 6-[3-(2-chloroethyl)- 
      3-nitrosoureido]-6-deoxy-alpha-D-glucopyranoside in experimental animals.
PG  - 937-46
AB  - A new water-soluble nitrosourea derivative, methyl 
      6-[3-(2-chloroethyl)-3-nitrosoureido]-6-deoxy-alpha-D-glucopyranoside (MCNU), was 
      tested for antitumor activity against murine tumors (L1210 and P388 leukemias, 
      B16 melanoma, and Lewis lung carcinoma) and BC-47 rat bladder carcinoma, and the 
      results were compared with those for four other nitrosourea derivatives; 
      chlorozotocin, 1-(2-chloroethyl)-3-(beta-D-glucopyranosyl)-1-nitrosourea (GANU), 
      3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1- nitrosourea 
      hydrochloride (ACNU), and 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea 
      (methyl-CCNU). MCNU was shown not only to have a broad antitumor spectrum against 
      all the tumors tested, but also to be effective over a wide range of dosages. The 
      antitumor activity of MCNU was superior to those of GANU and chlorozotocin and 
      similar to those of ACNU and methyl-CCNU. Furthermore, MCNU and other 
      nitrosoureas were evaluated for toxicity in BDF1 female mice with respect to body 
      weight changes. Weight loss in mice given MCNU at a dose lethal to 10% of the 
      mice was relatively mild and the treated mice regained body weight most rapidly 
      to the pretreatment level among all groups receiving the above drugs at equitoxic 
      doses. These results may suggest that MCNU is a new nitrosourea derivative 
      worthwhile to perform clinical trials.
FAU - Fujimoto, S
AU  - Fujimoto S
FAU - Tashiro, T
AU  - Tashiro T
FAU - Ogawa, M
AU  - Ogawa M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Japan
TA  - Gan
JT  - Gan
JID - 0151745
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Nitrosourea Compounds)
RN  - RYH2T97J77 (ranimustine)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/*therapeutic use
MH  - Cell Line
MH  - Leukemia L1210/drug therapy
MH  - Leukemia P388/drug therapy
MH  - Lung Neoplasms/drug therapy
MH  - Melanoma/drug therapy
MH  - Mice
MH  - Neoplasms, Experimental/*drug therapy
MH  - Nitrosourea Compounds/*therapeutic use/toxicity
MH  - Structure-Activity Relationship
MH  - Tumor Stem Cell Assay
MH  - Urinary Bladder Neoplasms/drug therapy
EDAT- 1984/10/01 00:00
MHDA- 1984/10/01 00:01
CRDT- 1984/10/01 00:00
PHST- 1984/10/01 00:00 [pubmed]
PHST- 1984/10/01 00:01 [medline]
PHST- 1984/10/01 00:00 [entrez]
PST - ppublish
SO  - Gan. 1984 Oct;75(10):937-46.