PMID- 6519747
OWN - NLM
STAT- MEDLINE
DCOM- 19850311
LR  - 20190722
IS  - 0194-911X (Print)
IS  - 0194-911X (Linking)
VI  - 6
IP  - 6 Pt 1
DP  - 1984 Nov-Dec
TI  - Role of dopamine in the development of spontaneous hypertension.
PG  - 899-905
AB  - To investigate the role of brain catecholamines in the development of spontaneous 
      hypertension, rats were treated with different doses of the neurotoxins 
      6-hydroxydopamine (6-OHDA) or DSP-4 (N-[2-chloroethyl]-N-ethyl-2-bromobenzylamine 
      hydrochloride). Intracerebroventricular (i.c.v.) 6-OHDA attenuated the 
      development of hypertension in spontaneously hypertensive rats (SHR) and also 
      lowered the systolic blood pressure (BP) in Wistar-Kyoto (WKY) and stroke-prone 
      spontaneously hypertensive rats (SHRSP). Norepinephrine was markedly and 
      dose-dependently depleted in brain areas of all three substrains. Dopamine was 
      affected also, although to a lesser extent. Pretreatment with the 
      norepinephrine-uptake inhibitor desmethylimipramine (DMI) did not influence the 
      effect of 6-OHDA on the development of hypertension in SHR. DMI largely 
      antagonized the 6-OHDA-induced depletion of brain norepinephrine, while dopamine 
      depletion was not affected. Specific depletion of brain norepinephrine by 
      treatment with DSP-4 did not alter the rise in BP in SHR. These results suggest 
      that the effect of 6-OHDA on the development of hypertension in SHR may not be 
      mediated through destruction of brain norepinephrine neurons, but that 
      interruption of brain dopaminergic mechanisms is a possibility in this respect.
FAU - van den Buuse, M
AU  - van den Buuse M
FAU - Versteeg, D H
AU  - Versteeg DH
FAU - de Jong, W
AU  - de Jong W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hypertension
JT  - Hypertension (Dallas, Tex. : 1979)
JID - 7906255
RN  - 0 (Benzylamines)
RN  - 0 (Hydroxydopamines)
RN  - PQ1P7JP5C1 (DSP 4)
RN  - TG537D343B (Desipramine)
RN  - VTD58H1Z2X (Dopamine)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Animals
MH  - Benzylamines/pharmacology
MH  - Blood Pressure/drug effects
MH  - Brain/*metabolism
MH  - Brain Chemistry/drug effects
MH  - Desipramine/pharmacology
MH  - Dopamine/analysis/metabolism/*physiology
MH  - Dose-Response Relationship, Drug
MH  - Hydroxydopamines/pharmacology
MH  - Hypertension/chemically induced/*physiopathology
MH  - Injections, Intraventricular
MH  - Male
MH  - Norepinephrine/analysis/metabolism
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
EDAT- 1984/11/01 00:00
MHDA- 1984/11/01 00:01
CRDT- 1984/11/01 00:00
PHST- 1984/11/01 00:00 [pubmed]
PHST- 1984/11/01 00:01 [medline]
PHST- 1984/11/01 00:00 [entrez]
AID - 10.1161/01.hyp.6.6.899 [doi]
PST - ppublish
SO  - Hypertension. 1984 Nov-Dec;6(6 Pt 1):899-905. doi: 10.1161/01.hyp.6.6.899.