PMID- 6519943 OWN - NLM STAT- MEDLINE DCOM- 19850225 LR - 20061115 IS - 0021-2180 (Print) IS - 0021-2180 (Linking) VI - 20 IP - 12 DP - 1984 Dec TI - Survey of immunoglobulin E levels in atopic families in Israel. PG - 1133-7 AB - Two hundred and ten members belonging to two consecutive generations of 41 atopic families (healthy and affected by clinical atopic manifestations) were investigated for basal immunoglobulin E (IgE) levels and clinical picture. The results show overall increased IgE levels, above standard values in the whole population studied, and a significant correlation between clinical atopy and high IgE levels in the children of the group. Within these families recessive inheritance of abnormally high IgE levels suggests that their high IgE levels are due to a genetically transmitted defect in IgE suppression. FAU - Geller-Bernstein, C AU - Geller-Bernstein C FAU - Weisglass, L AU - Weisglass L FAU - Keret, N AU - Keret N FAU - Dun, R AU - Dun R FAU - Kenett, R AU - Kenett R FAU - Bejerano, A AU - Bejerano A FAU - Lahav, M AU - Lahav M FAU - Sela, M AU - Sela M LA - eng PT - Comparative Study PT - Journal Article PL - Israel TA - Isr J Med Sci JT - Israel journal of medical sciences JID - 0013105 RN - 37341-29-0 (Immunoglobulin E) SB - IM MH - Adolescent MH - Adult MH - Age Factors MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Hypersensitivity, Immediate/blood/epidemiology/*genetics MH - Immunoglobulin E/*analysis/genetics MH - Israel MH - Male MH - Middle Aged MH - Pedigree MH - Skin Tests MH - Social Environment EDAT- 1984/12/01 00:00 MHDA- 1984/12/01 00:01 CRDT- 1984/12/01 00:00 PHST- 1984/12/01 00:00 [pubmed] PHST- 1984/12/01 00:01 [medline] PHST- 1984/12/01 00:00 [entrez] PST - ppublish SO - Isr J Med Sci. 1984 Dec;20(12):1133-7.