PMID- 6522485
OWN - NLM
STAT- MEDLINE
DCOM- 19850318
LR  - 20190712
IS  - 0031-9384 (Print)
IS  - 0031-9384 (Linking)
VI  - 33
IP  - 4
DP  - 1984 Oct
TI  - Male hamster copulatory responses to a high molecular weight fraction of vaginal 
      discharge: effects of vomeronasal organ removal.
PG  - 653-60
AB  - The importance of the vomeronasal (accessory olfactory) system for the copulatory 
      responses of male hamsters to a high molecular weight fraction (HMF) of vaginal 
      discharge was assessed in animals that had their vomeronasal organs (VNO) 
      removed. These organs were extirpated bilaterally using an oral approach through 
      the palate so as to eliminate the peripheral afferents to the accessory olfactory 
      bulb (AOB) with minimal or no damage to the main olfactory system. The selective 
      peripheral deafferentation procedure was verified by applying horseradish 
      peroxidase intranasally following intraperitoneal injections of epinephrine to 
      facilitate the vomeronasal pumping mechanism that draws fluids into the VNO. 
      Heavy, bilateral anterograde labeling was evident in the olfactory nerve 
      afferents within the main olfactory bulb of males that had their VNO removed and 
      of animals that received sham surgery. Sham-operated males also had heavy, 
      bilateral labeling in the vomeronasal nerve afferents within the AOB, whereas no 
      such labeling occurred among animals with bilateral removal of the VNO. In 
      sham-operated animals, both the HMF and the unfractionated discharge 
      significantly increased the incidence of intromission attempts toward 
      anesthetized males (surrogate females) whose hindquarters were scented with these 
      stimuli. The unfractionated discharge also produced a significant elevation of 
      overt copulatory behavior in males with selective peripheral deafferentation of 
      the vomeronasal system, whereas the HMF did not facilitate copulatory behavior in 
      these animals.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Clancy, A N
AU  - Clancy AN
FAU - Macrides, F
AU  - Macrides F
FAU - Singer, A G
AU  - Singer AG
FAU - Agosta, W C
AU  - Agosta WC
LA  - eng
GR  - MH 08645/MH/NIMH NIH HHS/United States
GR  - NS 12344/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Pheromones)
RN  - 0 (Sex Attractants)
SB  - IM
MH  - Animals
MH  - Copulation/physiology
MH  - Cricetinae
MH  - Exploratory Behavior/physiology
MH  - Female
MH  - Male
MH  - Mesocricetus
MH  - Olfactory Mucosa/*physiology
MH  - Pheromones/*isolation & purification
MH  - Sex Attractants/*isolation & purification/physiology
MH  - Sexual Behavior, Animal/*physiology
MH  - Smell/physiology
MH  - Vagina/*analysis
EDAT- 1984/10/01 00:00
MHDA- 1984/10/01 00:01
CRDT- 1984/10/01 00:00
PHST- 1984/10/01 00:00 [pubmed]
PHST- 1984/10/01 00:01 [medline]
PHST- 1984/10/01 00:00 [entrez]
AID - 0031-9384(84)90386-X [pii]
AID - 10.1016/0031-9384(84)90386-x [doi]
PST - ppublish
SO  - Physiol Behav. 1984 Oct;33(4):653-60. doi: 10.1016/0031-9384(84)90386-x.