PMID- 6530514
OWN - NLM
STAT- MEDLINE
DCOM- 19850426
LR  - 20221207
IS  - 0391-4097 (Print)
IS  - 0391-4097 (Linking)
VI  - 7
IP  - 6
DP  - 1984 Dec
TI  - Influence of continuous subcutaneous insulin infusion (CSII) treatment on 
      diabetic somatic and autonomic neuropathy.
PG  - 623-8
AB  - Near-normal plasma daily glucose profile was induced by Continuous Subcutaneous 
      Insulin Infusion (CSII) treatment in order to evaluate its influence on diabetic 
      somatic and autonomic neuropathy. Twelve insulin-dependent diabetic subjects with 
      somatic neuropathy were studied before and after a short term CSII treatment of 
      10 days. Four out of these subjects, all affected by autonomic neuropathy, were 
      followed for 1 yr with controls every four months. Metabolic equilibrium was 
      monitored by mean daily plasma glucose (MPDG) profile and by Glycosylated 
      Hemoglobin (GHb) evaluation. Somatic neuropathy was studied assessing conduction 
      velocity at peroneal motor (PMCV) nerve, ulnar motor (UMCV), ulnar sensory (USCV) 
      and sural sensory (SSCV) nerves. Autonomic neuropathy was assessed by means of a 
      battery of five cardiovascular autonomic tests: Valsalva Manoeuvre (VR), Deep 
      Breathing (DB), Lying-to-Standing (LS), Sustained HandGrip (SHG) and Postural 
      Hypotension (PH). Short-term CSII treatment induced a near normalization of 
      metabolic parameters, a significant improvement in VR (p less than 0.05) and DB 
      (p less than 0.01) values, but no changes in NCV. The prolongation of CSII 
      treatment in 4 subjects induced a significant (p less than 0.05) improvement in 
      VR, DB and LS values and in PMCV and UMCV after 4 months. This improvement did 
      not increase with the longer CSII treatment (1 yr).(ABSTRACT TRUNCATED AT 250 
      WORDS)
FAU - Fedele, D
AU  - Fedele D
FAU - Negrin, P
AU  - Negrin P
FAU - Cardone, C
AU  - Cardone C
FAU - Bellavere, F
AU  - Bellavere F
FAU - Ferri, M
AU  - Ferri M
FAU - Briani, G
AU  - Briani G
FAU - Nosadini, R
AU  - Nosadini R
FAU - Crepaldi, G
AU  - Crepaldi G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Italy
TA  - J Endocrinol Invest
JT  - Journal of endocrinological investigation
JID - 7806594
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Blood Glucose/analysis
MH  - Blood Pressure
MH  - Diabetic Neuropathies/*drug therapy/physiopathology
MH  - Female
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - *Insulin Infusion Systems
MH  - Male
MH  - Middle Aged
MH  - Posture
MH  - Reflex/physiology
MH  - Respiration
MH  - Valsalva Maneuver
EDAT- 1984/12/01 00:00
MHDA- 1984/12/01 00:01
CRDT- 1984/12/01 00:00
PHST- 1984/12/01 00:00 [pubmed]
PHST- 1984/12/01 00:01 [medline]
PHST- 1984/12/01 00:00 [entrez]
AID - 10.1007/BF03349496 [doi]
PST - ppublish
SO  - J Endocrinol Invest. 1984 Dec;7(6):623-8. doi: 10.1007/BF03349496.