PMID- 6533030
OWN - NLM
STAT- MEDLINE
DCOM- 19850620
LR  - 20161123
IS  - 0300-5038 (Print)
IS  - 0300-5038 (Linking)
IP  - 57
DP  - 1984
TI  - Distribution and metabolism of N-nitrosobis(2-hydroxypropyl)amine in rats.
PG  - 411-6
AB  - The metabolic fate of the lung carcinogen N-nitrosobis(2-hydroxypropyl)amine 
      (ND2HPA) in male Wistar rats was studied. The blood level after a single 
      intraperitoneal (i.p.) injection of [1-14C]-ND2HPA at a dose of 3 g/kg body 
      weight reached a maximum within 1 h. Most of the administered 14C was eliminated 
      via the urine; 90.8% of the 14C was excreted in urine within 24 h, 5.5% in 
      faeces, and 3.2% in expired air. About 11% of the 14C was detected in bile 
      collected over 24 h. A relatively high concentration of 14C was found in the 
      blood and target organs, such as the lung, liver, thyroid gland and kidney 1 h 
      after treatment. Analysis by high-pressure liquid chromatography showed that the 
      14C in the blood and urine was mostly accounted for by unchanged ND2HPA, together 
      with smaller amounts of N-nitroso-(2-hydroxypropyl)(2-oxopropyl)amine (N2HP2OPA). 
      ND2HPA and N2HP2OPA were also detected in the lung and liver of rats 30 min to 12 
      h after the administration and were present in higher concentrations in the blood 
      and lung than in the liver and pancreas. Besides ND2HPA and N2HP2OPA. 
      N-nitrosomethyl(2-hydroxypropyl)amine (NM2HPA) was also found in urine collected 
      over 6 h. ND2HPA, N2HP2OPA and NM2HPA showed mutagenicity in the Salmonella assay 
      system with metabolic activation by a 9000 X g supernatant of rat liver, and 
      N2HP2OPA was also mutagenic in the presence of a rat lung preparation. These data 
      suggest that N2HP2OPA and NM2HPA might be important intermediates in the 
      metabolic activation of ND2HPA to its ultimate carcinogenic form in rats.
FAU - Mori, Y
AU  - Mori Y
FAU - Takahashi, H
AU  - Takahashi H
FAU - Yamazaki, H
AU  - Yamazaki H
FAU - Toyoshi, K
AU  - Toyoshi K
FAU - Obara, T
AU  - Obara T
FAU - Makino, T
AU  - Makino T
FAU - Nakae, D
AU  - Nakae D
FAU - Takahashi, S
AU  - Takahashi S
FAU - Konishi, Y
AU  - Konishi Y
LA  - eng
PT  - Journal Article
PL  - France
TA  - IARC Sci Publ
JT  - IARC scientific publications
JID - 8009542
RN  - 0 (Carcinogens)
RN  - 0 (Nitrosamines)
RN  - 4J072HB2ND (diisopropanolnitrosamine)
SB  - IM
MH  - Animals
MH  - Carcinogens/*metabolism
MH  - Male
MH  - Nitrosamines/*metabolism
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Tissue Distribution
EDAT- 1984/01/01 00:00
MHDA- 1984/01/01 00:01
CRDT- 1984/01/01 00:00
PHST- 1984/01/01 00:00 [pubmed]
PHST- 1984/01/01 00:01 [medline]
PHST- 1984/01/01 00:00 [entrez]
PST - ppublish
SO  - IARC Sci Publ. 1984;(57):411-6.