PMID- 6533034
OWN - NLM
STAT- MEDLINE
DCOM- 19850620
LR  - 20161123
IS  - 0300-5038 (Print)
IS  - 0300-5038 (Linking)
IP  - 57
DP  - 1984
TI  - Determination of N-nitrosobis(2-hydroxypropyl)amine in environmental samples.
PG  - 43-50
AB  - N-Nitrosobis(2-hydroxypropyl)amine (ND2HPA) is a potent pancreatic carcinogen in 
      hamsters and induces gastrointestinal and respiratory tract cancer in rats. The 
      precursor amines, diisopropanolamine (Di-PA) and triisopropanolamine (Ti-PA), are 
      used in some manufacturing processes and in cosmetic preparations. We have found 
      low levels of ND2HPA in commercial Ti-PA (21-270 ng/g) and in Di-PA (20-1 300 
      ng/g) and have demonstrated that ND2HPA is formed from Ti-PA and nitrite in a 
      yield comparable to that observed for formation of N-nitrosodiethanolamine 
      (NDELA) from triethanolamine under relatively mild conditions. After reaction for 
      4 h at 37 degrees C (10 mmol/L amine, 40 mmol/L nitrite, pH 3.0), the ND2HPA 
      yield was 0.51%. The NDELA yield under the same conditions was 0.96%. ND2HPA was 
      determined by gas chromatography-thermal energy analysis (GC-TEA) and 
      GC-high-resolution mass spectrometry (GC-MS) selected ion monitoring of the 
      tert-butyldimethylsilyl (t-BDMS) ether after extraction on a Celite 560 column. 
      The t-BDMS ethers of ND2HPA and NDELA yielded intense, structurally significant 
      peaks at m/z 333.2030 and 305.1716, respectively. The GC-MS procedure provides 
      sensitivity and selectivity comparable to that of GC-TEA.
FAU - Issenberg, P
AU  - Issenberg P
FAU - Conrad, E E
AU  - Conrad EE
FAU - Nielsen, J W
AU  - Nielsen JW
FAU - Klein, D A
AU  - Klein DA
FAU - Miller, S E
AU  - Miller SE
LA  - eng
GR  - N01-CP33278/CP/NCI NIH HHS/United States
GR  - R01 CA-29197/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - France
TA  - IARC Sci Publ
JT  - IARC scientific publications
JID - 8009542
RN  - 0 (Carcinogens, Environmental)
RN  - 0 (Nitrosamines)
RN  - 4J072HB2ND (diisopropanolnitrosamine)
SB  - IM
MH  - Carcinogens, Environmental/*analysis
MH  - Chromatography, Gas
MH  - Gas Chromatography-Mass Spectrometry
MH  - Mass Spectrometry
MH  - Nitrosamines/*analysis
EDAT- 1984/01/01 00:00
MHDA- 1984/01/01 00:01
CRDT- 1984/01/01 00:00
PHST- 1984/01/01 00:00 [pubmed]
PHST- 1984/01/01 00:01 [medline]
PHST- 1984/01/01 00:00 [entrez]
PST - ppublish
SO  - IARC Sci Publ. 1984;(57):43-50.