PMID- 6541093
OWN - NLM
STAT- MEDLINE
DCOM- 19841116
LR  - 20190720
IS  - 0304-3835 (Print)
IS  - 0304-3835 (Linking)
VI  - 24
IP  - 2
DP  - 1984 Sep
TI  - The relationship of colonic carcinogenesis and hepatic vascular tumors induced by 
      subcutaneously injected-1,2-dimethylhydrazine dihydrochloride in specific 
      pathogen free mice.
PG  - 313-20
AB  - 1,2-Dimethylhydrazine dihydrochloride (DMH) is one of the most reliable 
      carcinogens for experimental colonic carcinogenesis. In order to evaluate the 
      biological significances of target organ specificity of DMH-induced 
      carcinogenesis, specific pathogen free (SPF) BALB/c mice were injected 
      subcutaneously with DMH for 30 weeks, and were studied pathologically for tumor 
      development of various organs. The data showed that colon tumor developed only at 
      2% of these mice. However, it produced 100% incidence of malignant endotheliomas 
      and angiosarcomas of blood vessels and these tumors selectively appeared in the 
      liver. There were no overt foci of primary vascular tumors in the heart, lung, 
      kidney, muscle as well as spleen. This tumor model may reveal that the organ 
      specificity of the carcinogenic activity with DMH could be converted, possibly 
      depending upon the bacterial flora in the intestines, and very suitable for the 
      investigation of implications of intestinal bacteria on the colonic and vascular 
      tumorigenesis.
FAU - Sato, N
AU  - Sato N
FAU - Kaku, T
AU  - Kaku T
FAU - Dempo, K
AU  - Dempo K
FAU - Kikuchi, K
AU  - Kikuchi K
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
RN  - 0 (Carcinogens)
RN  - 0 (Dimethylhydrazines)
RN  - IX068S9745 (1,2-Dimethylhydrazine)
SB  - IM
MH  - 1,2-Dimethylhydrazine
MH  - Animals
MH  - Carcinogens/toxicity
MH  - Colonic Neoplasms/*chemically induced/pathology
MH  - Dimethylhydrazines/toxicity
MH  - Female
MH  - Germ-Free Life
MH  - Hemangioendothelioma/*chemically induced/pathology
MH  - Hemangiosarcoma/*chemically induced/pathology
MH  - Liver Neoplasms/*chemically induced/pathology
MH  - Mice
MH  - Mice, Inbred BALB C
EDAT- 1984/09/01 00:00
MHDA- 1984/09/01 00:01
CRDT- 1984/09/01 00:00
PHST- 1984/09/01 00:00 [pubmed]
PHST- 1984/09/01 00:01 [medline]
PHST- 1984/09/01 00:00 [entrez]
AID - 0304-3835(84)90139-3 [pii]
AID - 10.1016/0304-3835(84)90139-3 [doi]
PST - ppublish
SO  - Cancer Lett. 1984 Sep;24(2):313-20. doi: 10.1016/0304-3835(84)90139-3.