PMID- 6542021
OWN - NLM
STAT- MEDLINE
DCOM- 19841226
LR  - 20191023
IS  - 0007-5124 (Print)
IS  - 0007-5124 (Linking)
VI  - 33
IP  - 3
DP  - 1984 Jul
TI  - Anemia and potassium permeability of red blood cells in analbuminemic rats.
PG  - 307-18
AB  - A mutant strain, Nagase analbuminemia rats (NAR), was established from 
      Sprague-Dawley rats. Hematological evaluations were made on NAR of 4 to 52 weeks 
      of age. NAR had an abnormally low number of red blood cells (RBC), a low 
      hematocrit, a reduced hemoglobin concentration and an increased number of 
      reticulocytes. Their plasma electrolyte level was normal. Osmotic fragility of 
      RBC was slightly increased in the rats. Thus NAR shows a slight anemia. The in 
      vitro experiments on RBC were performed. The incubation of blood showed a 
      hemolytic tendency and elevated potassium efflux in the blood of NAR. In 
      addition, an increased efflux of potassium was found in the RBC of NAR, when the 
      RBC was washed with phosphate buffered saline and then was incubated with the 
      saline containing CaCl2. This potassium efflux was prevented in the presence of 
      rat albumin. These findings suggest that the deficiency of serum albumin may 
      increase the permeability of potassium in erythrocyte membrane in NAR.
FAU - Sugiyama, K
AU  - Sugiyama K
FAU - Emori, T
AU  - Emori T
FAU - Shumiya, S
AU  - Shumiya S
FAU - Nagase, S
AU  - Nagase S
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Jikken Dobutsu
JT  - Jikken dobutsu. Experimental animals
JID - 1256412
RN  - 0 (Electrolytes)
RN  - 0 (Lipids)
RN  - 0 (Serum Albumin)
RN  - RWP5GA015D (Potassium)
SB  - IM
MH  - Anemia, Hemolytic/blood/*veterinary
MH  - Animals
MH  - Cell Membrane Permeability
MH  - Electrolytes/blood
MH  - Erythrocyte Membrane/*metabolism
MH  - Female
MH  - Hemolysis
MH  - Lipids/blood
MH  - Male
MH  - Mice
MH  - Mice, Mutant Strains/*blood
MH  - Osmotic Fragility
MH  - Potassium/*blood
MH  - Rats
MH  - Rodent Diseases/*blood
MH  - Serum Albumin/*deficiency
EDAT- 1984/07/01 00:00
MHDA- 1984/07/01 00:01
CRDT- 1984/07/01 00:00
PHST- 1984/07/01 00:00 [pubmed]
PHST- 1984/07/01 00:01 [medline]
PHST- 1984/07/01 00:00 [entrez]
AID - 10.1538/expanim1978.33.3_307 [doi]
PST - ppublish
SO  - Jikken Dobutsu. 1984 Jul;33(3):307-18. doi: 10.1538/expanim1978.33.3_307.