PMID- 6543363
OWN - NLM
STAT- MEDLINE
DCOM- 19850516
LR  - 20190511
IS  - 0021-924X (Print)
IS  - 0021-924X (Linking)
VI  - 96
IP  - 6
DP  - 1984 Dec
TI  - Penetration of bilirubin into the brain in albumin-deficient and jaundiced rats 
      (AJR) and Nagase analbuminemic rats (NAR).
PG  - 1705-12
AB  - An albumin-deficient and jaundiced strain of rats (AJR) was established by 
      crossing Nagase analbuminemic rats (NAR) with jaundiced Gunn rats. AJR have no 
      serum albumin and die with kernicterus within 3 weeks after birth. Their serum 
      bilirubin level was 25 per cent (20 micrograms/ml) of that of Gunn rats at 1-2 
      weeks of age, while their brain bilirubin content was 1.2-2.7 times (4-5 
      micrograms/g brain) that of Gunn rats. Binding of bilirubin to NAR plasma 
      proteins was examined. The bilirubin binding protein in NAR plasma was found to 
      be lipoprotein, showing an association constant of 6.7 X 10(6) M-1. 
      Bilirubin-transport into the brain of postnatal NAR was investigated by 
      intravenous infusion of bilirubin with taurocholate. The brain bilirubin level of 
      NAR infused with free bilirubin was 1.6 times that of normal rats. In NAR, the 
      brain level on infusion of lipoprotein-bound bilirubin was similar to that on 
      infusion of free bilirubin, but albumin-bound bilirubin scarcely entered the 
      brain. These findings suggest that lipoprotein-bound bilirubin can diffuse across 
      the blood-brain barrier into the brain.
FAU - Takahashi, M
AU  - Takahashi M
FAU - Sugiyama, K
AU  - Sugiyama K
FAU - Shumiya, S
AU  - Shumiya S
FAU - Nagase, S
AU  - Nagase S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Biochem
JT  - Journal of biochemistry
JID - 0376600
RN  - 0 (Albumins)
RN  - 0 (Carrier Proteins)
RN  - 0 (Lipoproteins)
RN  - 0 (bilirubin binding protein, human)
RN  - 0 (bilirubin binding protein, rat)
RN  - RFM9X3LJ49 (Bilirubin)
SB  - IM
MH  - Aging
MH  - Albumins/*deficiency
MH  - Animals
MH  - Bilirubin/blood/*metabolism
MH  - Blood-Brain Barrier
MH  - Brain/*metabolism
MH  - Carrier Proteins/blood
MH  - Chromatography, Gel
MH  - Humans
MH  - Jaundice/*metabolism
MH  - Kernicterus/etiology
MH  - Lipoproteins/metabolism
MH  - Protein Binding
MH  - Rats
MH  - Rats, Gunn
MH  - Rats, Inbred Strains
EDAT- 1984/12/01 00:00
MHDA- 1984/12/01 00:01
CRDT- 1984/12/01 00:00
PHST- 1984/12/01 00:00 [pubmed]
PHST- 1984/12/01 00:01 [medline]
PHST- 1984/12/01 00:00 [entrez]
AID - 10.1093/oxfordjournals.jbchem.a135003 [doi]
PST - ppublish
SO  - J Biochem. 1984 Dec;96(6):1705-12. doi: 10.1093/oxfordjournals.jbchem.a135003.