PMID- 6552151
OWN - NLM
STAT- MEDLINE
DCOM- 19830610
LR  - 20210526
IS  - 0066-4804 (Print)
IS  - 1098-6596 (Electronic)
IS  - 0066-4804 (Linking)
VI  - 23
IP  - 3
DP  - 1983 Mar
TI  - In vitro susceptibility patterns of methicillin-resistant and-susceptible 
      Staphylococcus auerues strains in a population of parenteral drug abusers from 
      1972 to 1981.
PG  - 450-7
AB  - Since 1980, infections caused by methicillin-resistant (MR) Staphylococcus aureus 
      have been epidemic among Detroit-area parenteral drug abusers. Because of the 
      increasing importance of this pathogen, in vitro susceptibilities were compared 
      for 39 isolates of MR S. aureus from 1980 to 1981, and for 56 strains of 
      methicillin-susceptible (MS) S. aureus from 1972 to 1981, recovered from drug 
      abusers with community-acquired infections. Agar dilution studies were performed 
      at 35 degrees C, and minimal inhibitory concentrations were determined after 
      incubation for 18 and 48 h. MR S. aureus exhibited cross-resistance to other 
      beta-lactam antibiotics which frequently required 48 h for expression. MR S. 
      aureus isolates were also resistant to tetracycline, clindamycin, tobramycin, and 
      amikacin. All MR S. aureus isolates investigated synthesized an aminoglycoside 
      4'-nucleotidyltransferase. Emergence of resistance to cefotaxime, tetracycline, 
      and clindamycin was noted among current MS S. aureus isolates. Vancomycin, 
      fusidic acid, trimethoprim/sulfamethoxazole, and rifampin were the most active 
      agents against MR S. aureus and were equally effective against MS S. aureus.
FAU - Markowitz, N
AU  - Markowitz N
FAU - Pohlod, D J
AU  - Pohlod DJ
FAU - Saravolatz, L D
AU  - Saravolatz LD
FAU - Quinn, E L
AU  - Quinn EL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Antimicrob Agents Chemother
JT  - Antimicrobial agents and chemotherapy
JID - 0315061
RN  - 0 (Anti-Bacterial Agents)
RN  - Q91FH1328A (Methicillin)
SB  - IM
MH  - Anti-Bacterial Agents/*pharmacology
MH  - Humans
MH  - Injections
MH  - Methicillin/*pharmacology
MH  - Microbial Sensitivity Tests
MH  - Penicillin Resistance
MH  - R Factors
MH  - Staphylococcal Infections/drug therapy
MH  - Staphylococcus aureus/*drug effects
MH  - Substance-Related Disorders/*microbiology
MH  - Time Factors
PMC - PMC184668
EDAT- 1983/03/01 00:00
MHDA- 1983/03/01 00:01
PMCR- 1983/03/01
CRDT- 1983/03/01 00:00
PHST- 1983/03/01 00:00 [pubmed]
PHST- 1983/03/01 00:01 [medline]
PHST- 1983/03/01 00:00 [entrez]
PHST- 1983/03/01 00:00 [pmc-release]
AID - 10.1128/AAC.23.3.450 [doi]
PST - ppublish
SO  - Antimicrob Agents Chemother. 1983 Mar;23(3):450-7. doi: 10.1128/AAC.23.3.450.