PMID- 6578858
OWN - NLM
STAT- MEDLINE
DCOM- 19831217
LR  - 20190904
IS  - 0006-5242 (Print)
IS  - 0006-5242 (Linking)
VI  - 47
IP  - 5
DP  - 1983 Nov
TI  - Acute lymphoblastic leukemia hand-mirror cells. Study of nine cases.
PG  - 297-306
AB  - Acute lymphoblastic leukemia with hand-mirror cells (HMC) was diagnosed in nine 
      adult patients. Blast HMC were seen only in the bone marrow (12-57% range). 
      Cytochemical studies revealed a positive reaction to tartrate-sensitive acid 
      phosphatase in the tail portion of the cells in seven cases, with a strong, 
      localized cytoplasmic reaction in four. Leukemic cells lacked surface 
      immunoglobulins and were E rosette negative in all cases. Normal levels of 
      adenosine deaminase activity (ADA) were found in five of the seven patients. 
      Electron microscope studies confirmed the hand-mirror shape of the cell. These 
      HMC contained large numbers of mitochondria and microspikes in the handle portion 
      of the cell. The patients failed to respond to initial conventional ALL 
      chemotherapy, but the prolonged survival with passable health of the majority of 
      these, despite their lack of complete remission, is emphasized.
FAU - Liso, V
AU  - Liso V
FAU - Specchia, G
AU  - Specchia G
FAU - Pavone, V
AU  - Pavone V
FAU - Colotta, F
AU  - Colotta F
FAU - Riezzo, A
AU  - Riezzo A
FAU - Ferrannini, A
AU  - Ferrannini A
FAU - Tursi, A
AU  - Tursi A
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Blut
JT  - Blut
JID - 0173401
RN  - 0 (Antibodies, Monoclonal)
RN  - EC 3.1.3.2 (Acid Phosphatase)
RN  - EC 3.5.4.4 (Adenosine Deaminase)
SB  - IM
MH  - Acid Phosphatase/blood
MH  - Adenosine Deaminase/blood
MH  - Antibodies, Monoclonal/immunology
MH  - *Bone Marrow Cells
MH  - Histocytochemistry
MH  - Humans
MH  - Leukemia, Lymphoid/*blood
MH  - Lymphocytes/*cytology/enzymology/immunology/ultrastructure
MH  - Prognosis
EDAT- 1983/11/01 00:00
MHDA- 1983/11/01 00:01
CRDT- 1983/11/01 00:00
PHST- 1983/11/01 00:00 [pubmed]
PHST- 1983/11/01 00:01 [medline]
PHST- 1983/11/01 00:00 [entrez]
AID - 10.1007/BF00319899 [doi]
PST - ppublish
SO  - Blut. 1983 Nov;47(5):297-306. doi: 10.1007/BF00319899.