PMID- 6594246
OWN - NLM
STAT- MEDLINE
DCOM- 19850117
LR  - 20170920
IS  - 0015-0282 (Print)
IS  - 0015-0282 (Linking)
VI  - 42
IP  - 6
DP  - 1984 Dec
TI  - Clinical, immunologic, and genetic definitions of primary and secondary recurrent 
      spontaneous abortions.
PG  - 849-55
AB  - Fifty couples with repeated pregnancy failures were grouped by clinical history 
      as being primary (no children) or secondary (abortions subsequent to having 
      children or stillbirths) aborters. Human leukocyte antigen (HLA) sharing between 
      husband and wife and maternal antipaternal immunity were studied in both groups. 
      Analyses showed significantly more HLA-A, B, and DR locus antigens shared in the 
      primary abortion group than in the secondary abortion group (P = 0.01). The 
      number of couples sharing two to five HLA antigens was higher for those couples 
      with primary abortions than for secondary abortions (P = 0.009). Antipaternal 
      immunity as measured by visual complement-dependent lymphocytotoxicity (CDCE), by 
      51Cr release (CDC51Cr), and by complement-independent, antibody-dependent 
      cell-mediated cytotoxic (ADCC) assays was different between the two groups. CDCE 
      was not present in the primary aborters' sera but was found in 13 of the 15 
      secondary aborters' sera (P = 0.0001). Similarly, ADCC was not apparent in 
      primary aborters but was present in 14 of the 15 secondary aborters (P = 0.0001). 
      CDC51Cr was detected in 3 of the 11 primary aborters and in 13 of the 15 
      secondary aborters (P = 0.008). Such differences in HLA sharing and immune 
      reactivities between these two groups strengthen the idea that either inadequate 
      or inappropriately vigorous maternal antipaternal immunity can be related to 
      spontaneous abortions. These results uphold a central role for immunology in 
      human reproduction and provide further support for the use of immunotherapy to 
      prevent pregnancy losses in certain abortion-prone women.
FAU - McIntyre, J A
AU  - McIntyre JA
FAU - McConnachie, P R
AU  - McConnachie PR
FAU - Taylor, C G
AU  - Taylor CG
FAU - Faulk, W P
AU  - Faulk WP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
RN  - 0 (Antigens)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Abortion, Habitual/classification/genetics/*immunology
MH  - Adult
MH  - Antigens/immunology
MH  - Cytotoxicity Tests, Immunologic
MH  - Female
MH  - HLA Antigens/*analysis
MH  - HLA-A Antigens
MH  - HLA-B Antigens
MH  - HLA-C Antigens
MH  - HLA-DR Antigens
MH  - Histocompatibility Antigens Class II/*analysis
MH  - Humans
MH  - Lymphocytes/immunology
MH  - Male
MH  - Pregnancy
MH  - Trophoblasts/immunology
OID - CPC: S-2461-107-1
OID - POP: 00148900
OTO - PIP
OT  - *Abortion, Spontaneous
OT  - *Antibodies
OT  - Biology
OT  - *Couples
OT  - Diseases
OT  - *Drugs
OT  - Family And Household
OT  - Family Characteristics
OT  - *Genetics
OT  - Immunity
OT  - Immunologic Factors
OT  - Physiology
OT  - Pregnancy Complications
OT  - Treatment
GN  - PIP: TJ: FERTILITY AND STERILITY
EDAT- 1984/12/01 00:00
MHDA- 1984/12/01 00:01
CRDT- 1984/12/01 00:00
PHST- 1984/12/01 00:00 [pubmed]
PHST- 1984/12/01 00:01 [medline]
PHST- 1984/12/01 00:00 [entrez]
AID - S0015-0282(16)48255-5 [pii]
PST - ppublish
SO  - Fertil Steril. 1984 Dec;42(6):849-55.