PMID- 6594532
OWN - NLM
STAT- MEDLINE
DCOM- 19841226
LR  - 20171116
IS  - 0021-4949 (Print)
IS  - 0021-4949 (Linking)
VI  - 30
IP  - 11
DP  - 1984 Sep
TI  - [Post therapeutic myeloblastic leukemia in non-Hodgkin's lymphoma].
PG  - 1422-8
AB  - A 28-year-old man developed AML 18 months after a diagnosis of non-Hodgkin's 
      lymphoma, diffuse small cell type, clinical stage IIA. Induction therapy for the 
      lymphoma consisted 60Co 4000 rads bilaterally to the cervical areas and 2000 rads 
      to the right cervical area. Complete remission was attained. Nineteen courses of 
      combination chemotherapy with Vincristine (VCR), 6-meraptopurine (6 MP), 
      cyclophosphamide (CY) and predonisolone (pred) was added (Total dose: VCR; 26.5 
      mg, 6 MP; 3320 mg, CY; 3350 mg, pred; 4310 mg). Seven days after the final 
      chemotherapeutic treatment he developed AML with DIC. Leukemic cells were 
      peroxidase and specific esterase (naphthol AS-D chloroacetate) positive. 
      Induction therapy for the AML consisting of DCMP (Daunomycin, Cytosine 
      arabinosid, 6 MP and pred) and VCR (vindesine, CY and pred) was unsuccessful. The 
      patient died of cranial hemorrhage 3 month after the diagnosis of acute leukemia. 
      Autopsy revealed no recurrence of non-Hodgkin's lymphoma in the lymph nodes, bone 
      marrow, spleen and liver. Seven other cases reported in the Japanese literature 
      are reviewed.
FAU - Maekawa, I
AU  - Maekawa I
FAU - Kawamura, T
AU  - Kawamura T
FAU - Miyake, T
AU  - Miyake T
LA  - jpn
PT  - Case Reports
PT  - Journal Article
PL  - Japan
TA  - Gan No Rinsho
JT  - Gan no rinsho. Japan journal of cancer clinics
JID - 1257753
RN  - 5J49Q6B70F (Vincristine)
RN  - 8N3DW7272P (Cyclophosphamide)
RN  - 9PHQ9Y1OLM (Prednisolone)
RN  - E7WED276I5 (Mercaptopurine)
SB  - IM
MH  - Adult
MH  - Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
MH  - Cyclophosphamide/administration & dosage
MH  - Disseminated Intravascular Coagulation/etiology
MH  - Drug Administration Schedule
MH  - Humans
MH  - Leukemia, Myeloid, Acute/*etiology
MH  - Lymphoma/drug therapy/radiotherapy/*therapy
MH  - Male
MH  - Mercaptopurine/administration & dosage
MH  - Prednisolone/administration & dosage
MH  - Radiotherapy Dosage
MH  - Vincristine/administration & dosage
EDAT- 1984/09/01 00:00
MHDA- 1984/09/01 00:01
CRDT- 1984/09/01 00:00
PHST- 1984/09/01 00:00 [pubmed]
PHST- 1984/09/01 00:01 [medline]
PHST- 1984/09/01 00:00 [entrez]
PST - ppublish
SO  - Gan No Rinsho. 1984 Sep;30(11):1422-8.