PMID- 6598258
OWN - NLM
STAT- MEDLINE
DCOM- 19850619
LR  - 20190904
IS  - 0365-5237 (Print)
IS  - 0365-5237 (Linking)
VI  - 414
DP  - 1984
TI  - Atopic allergy and otitis media with effusion.
PG  - 108-14
AB  - To investigate the possible role of type 1 allergy in OME, the immunoglobulin E 
      (IgE) content was determined in 58 middle ear effusions and matched sera, 
      obtained from children with otitis media with effusion (OME). The IgE levels were 
      assayed for IgE by the Phadebas paper radio immunosorbent test (PRIST). Eight 
      cases (14%) showed elevated serum IgE levels, such that an atopic disorder was 
      very likely. However, in nearly all cases the effusion/serum ratio (E/S) was less 
      than one, showing a higher IgE level in the serum than in the effusion. A 
      modified PAP technique for determining surface IgE on mast cells is presented. 
      Positive results were obtained on nasal mucosa specimens in atopic patients with 
      OME but further research on middle ear mucosa in OME is needed. Our results fail 
      to support the concept of type 1 allergy as a major causative factor in OME.
FAU - Boedts, D
AU  - Boedts D
FAU - De Groote, G
AU  - De Groote G
FAU - Van Vuchelen, J
AU  - Van Vuchelen J
LA  - eng
PT  - Journal Article
PL  - Norway
TA  - Acta Otolaryngol Suppl
JT  - Acta oto-laryngologica. Supplementum
JID - 0370355
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - Chronic Disease
MH  - Ear, Middle/immunology
MH  - Exudates and Transudates/immunology
MH  - Humans
MH  - Hypersensitivity, Immediate/complications/*immunology
MH  - Immunoglobulin E/analysis
MH  - Infant
MH  - Mast Cells/immunology
MH  - Mucous Membrane/immunology
MH  - Nasal Mucosa/immunology
MH  - Otitis Media/*immunology
MH  - Otitis Media with Effusion/etiology/*immunology
EDAT- 1984/01/01 00:00
MHDA- 1984/01/01 00:01
CRDT- 1984/01/01 00:00
PHST- 1984/01/01 00:00 [pubmed]
PHST- 1984/01/01 00:01 [medline]
PHST- 1984/01/01 00:00 [entrez]
AID - 10.3109/00016488409122890 [doi]
PST - ppublish
SO  - Acta Otolaryngol Suppl. 1984;414:108-14. doi: 10.3109/00016488409122890.