PMID- 6603182
OWN - NLM
STAT- MEDLINE
DCOM- 19830811
LR  - 20171116
IS  - 0003-0805 (Print)
IS  - 0003-0805 (Linking)
VI  - 128
IP  - 1
DP  - 1983 Jul
TI  - Transfusion-related acute lung injury associated with passive transfer of 
      antileukocyte antibodies.
PG  - 185-9
AB  - Acute lung injury (ALI) is an infrequently recognized complication of transfusion 
      therapy. Although the role of passive transfer of leukoagglutinating antibodies 
      has been acknowledged, there is little documentation of the relationship of these 
      antibodies in transfused blood to the human leukocyte antigen (HLA) phenotype of 
      the recipient. Recently, we observed 5 cases of transfusion-related ALI, and in 
      all cases leukoagglutinating and lymphocytotoxic antibodies were found in serums 
      of the transfused blood products. In 3 cases, the antibodies corresponded to the 
      HLA antigens of the recipient. Multiparous blood donors whose plasma contains 
      these antibodies represent a potential transfusion hazard. It is recommended that 
      blood component usage from donors implicated in these reactions be restricted to 
      frozen or washed red blood cells. The incidence of leukoagglutinin-associated ALI 
      may be more frequent than previously appreciated. Current concepts of the 
      mechanism of microvascular pulmonary injury are discussed in relation to these 
      cases.
FAU - Popovsky, M A
AU  - Popovsky MA
FAU - Abel, M D
AU  - Abel MD
FAU - Moore, S B
AU  - Moore SB
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Am Rev Respir Dis
JT  - The American review of respiratory disease
JID - 0370523
RN  - 0 (Agglutinins)
RN  - 0 (Antibodies)
RN  - 0 (HLA Antigens)
RN  - 0 (Proteins)
RN  - 0 (leukoagglutinins, leukocytes)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Aged
MH  - Agglutinins/analysis
MH  - Antibodies/analysis
MH  - Antibody Specificity
MH  - Female
MH  - HLA Antigens/immunology
MH  - Humans
MH  - Immunization, Passive/*adverse effects
MH  - Leukocytes/*immunology
MH  - Male
MH  - Middle Aged
MH  - Proteins
MH  - Pulmonary Edema/*etiology/immunology
MH  - T-Lymphocytes, Cytotoxic/immunology
MH  - *Transfusion Reaction
EDAT- 1983/07/01 00:00
MHDA- 1983/07/01 00:01
CRDT- 1983/07/01 00:00
PHST- 1983/07/01 00:00 [pubmed]
PHST- 1983/07/01 00:01 [medline]
PHST- 1983/07/01 00:00 [entrez]
AID - 10.1164/arrd.1983.128.1.185 [doi]
PST - ppublish
SO  - Am Rev Respir Dis. 1983 Jul;128(1):185-9. doi: 10.1164/arrd.1983.128.1.185.