PMID- 6607783
OWN - NLM
STAT- MEDLINE
DCOM- 19840402
LR  - 20190829
IS  - 0344-5704 (Print)
IS  - 0344-5704 (Linking)
VI  - 12
IP  - 2
DP  - 1984
TI  - Disturbance of 6-mercaptopurine metabolism by cotrimoxazole in childhood 
      lymphoblastic leukaemia.
PG  - 87-9
AB  - The effect of cotrimoxazole on the utilization of 6-mercaptopurine (6MP) was 
      studied in a group of children receiving remission maintenance treatment for 
      lymphoblastic leukaemia (ALL). This was done by measuring the level of an active 
      metabolite of 6MP, 6-thioguanine nucleotide (6TGN), and comparing it both with 
      the drug dose and with subsequent neutropenia in the presence or absence of 
      concurrent cotrimoxazole. In children who were not taken cotrimoxazole, the 
      concentration of 6TGN showed a significant positive correlation with the dose and 
      a significant negative correlation with the absolute neutrophil count 2 weeks 
      later. In those who were taking the antibiotic both these relationships were 
      lost. This suggests that cotrimoxazole can interfere with both the absorption and 
      the cytotoxicity of 6MP and may, in turn, alter its antileukaemic effect.
FAU - Rees, C A
AU  - Rees CA
FAU - Lennard, L
AU  - Lennard L
FAU - Lilleyman, J S
AU  - Lilleyman JS
FAU - Maddocks, J L
AU  - Maddocks JL
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Cancer Chemother Pharmacol
JT  - Cancer chemotherapy and pharmacology
JID - 7806519
RN  - 0 (Drug Combinations)
RN  - 0 (Guanine Nucleotides)
RN  - 0 (Thionucleotides)
RN  - 15867-02-4 (6-thioguanylic acid)
RN  - 8064-90-2 (Trimethoprim, Sulfamethoxazole Drug Combination)
RN  - AN164J8Y0X (Trimethoprim)
RN  - E7WED276I5 (Mercaptopurine)
RN  - JE42381TNV (Sulfamethoxazole)
SB  - IM
MH  - Absorption
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Drug Combinations/pharmacology
MH  - Drug Interactions
MH  - Female
MH  - Guanine Nucleotides/blood
MH  - Humans
MH  - Leukemia, Lymphoid/*drug therapy
MH  - Male
MH  - Mercaptopurine/*metabolism/therapeutic use
MH  - Sulfamethoxazole/*pharmacology
MH  - Thionucleotides/blood
MH  - Trimethoprim/*pharmacology
MH  - Trimethoprim, Sulfamethoxazole Drug Combination
EDAT- 1984/01/01 00:00
MHDA- 1984/01/01 00:01
CRDT- 1984/01/01 00:00
PHST- 1984/01/01 00:00 [pubmed]
PHST- 1984/01/01 00:01 [medline]
PHST- 1984/01/01 00:00 [entrez]
AID - 10.1007/BF00254595 [doi]
PST - ppublish
SO  - Cancer Chemother Pharmacol. 1984;12(2):87-9. doi: 10.1007/BF00254595.