PMID- 6618744
OWN - NLM
STAT- MEDLINE
DCOM- 19831123
LR  - 20190908
IS  - 0192-0561 (Print)
IS  - 0192-0561 (Linking)
VI  - 5
IP  - 3
DP  - 1983
TI  - Preventive effect of a quinonyl derivative of N-acetylmuramyl dipeptide, QMDP-66, 
      against adriamycin-induced ECG abnormalities in rats.
PG  - 245-51
AB  - The effects on adriamycin cardiotoxicity of an immunoadjuvant, 
      2-[2-acetamido-2-deoxy-6-0-[10-(2,3-dimethoxy-5-methyl-1, 4-benzo-quinon-6-yl) 
      decanoyl]-D-glucopyranos-3-0-yl]-D-propionyl-L-valyl D-isoglutamine methyl ester 
      (QMDP-66), and a reference compound, ubiquinone-10, were studied in Wistar Kyoto 
      (WKY) rats. Adriamycin, 1 mg/kg/day intra-peritoneally (i.p.) for 23 days, 
      elicited cardiotoxicity, as judged by widening of the QRS complexes in ECGs. 
      Electron microscopic examination of myocytes from the treated rats revealed many 
      cytoplasmic vacuoles possibly originating from deranged endoplasmic reticula or 
      mitochondria. In addition, the treatment significantly inhibited body weight 
      gain, and decreased ventricular weight. QMDP-66 alone, 1 mg/kg/day i.p. for 23 
      days, had no effect on the parameters described above. When QMDP-66 (1 mg/kg/day, 
      i.p.) or ubiquinone-10 (3 mg/kg/day, i.p.) was administered together with 
      adriamycin, the widening of the QRS complexes was significantly depressed, and 
      cytoplasmic vacuoles in myocytes were rarely observed. The QMDP-66 or 
      ubiquinone-10 treatment, however, did not alleviate the decrease in body weight 
      gain or ventricular weight due to adriamycin. Heart rate was not significantly 
      changed by any of the treatments. These findings suggest that QMDP-66 is an 
      effective antidote against adriamycin cardiotoxicity.
FAU - Shimamoto, N
AU  - Shimamoto N
FAU - Tanabe, M
AU  - Tanabe M
FAU - Shino, A
AU  - Shino A
FAU - Hirata, M
AU  - Hirata M
FAU - Kawaji, H
AU  - Kawaji H
FAU - Azuma, I
AU  - Azuma I
FAU - Fukuda, T
AU  - Fukuda T
FAU - Kobayashi, S
AU  - Kobayashi S
FAU - Yamamura, Y
AU  - Yamamura Y
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Immunopharmacol
JT  - International journal of immunopharmacology
JID - 7904799
RN  - 0 (Adjuvants, Immunologic)
RN  - 53678-77-6 (Acetylmuramyl-Alanyl-Isoglutamine)
RN  - 72921-52-9 (quinonyl-MDP-66)
RN  - 80168379AG (Doxorubicin)
SB  - IM
MH  - Acetylmuramyl-Alanyl-Isoglutamine/*analogs & derivatives/pharmacology
MH  - Adjuvants, Immunologic/*pharmacology
MH  - Animals
MH  - Body Weight/drug effects
MH  - Doxorubicin/*toxicity
MH  - Electrocardiography
MH  - Heart/*drug effects
MH  - Heart Rate/drug effects
MH  - Male
MH  - Microscopy, Electron
MH  - Myocardium/ultrastructure
MH  - Organ Size/drug effects
MH  - Rats
MH  - Rats, Inbred Strains
EDAT- 1983/01/01 00:00
MHDA- 1983/01/01 00:01
CRDT- 1983/01/01 00:00
PHST- 1983/01/01 00:00 [pubmed]
PHST- 1983/01/01 00:01 [medline]
PHST- 1983/01/01 00:00 [entrez]
AID - 0192-0561(83)90062-0 [pii]
AID - 10.1016/0192-0561(83)90062-0 [doi]
PST - ppublish
SO  - Int J Immunopharmacol. 1983;5(3):245-51. doi: 10.1016/0192-0561(83)90062-0.