PMID- 6619649
OWN - NLM
STAT- MEDLINE
DCOM- 19831123
LR  - 20180206
IS  - 0022-2143 (Print)
IS  - 0022-2143 (Linking)
VI  - 102
IP  - 4
DP  - 1983 Oct
TI  - Total body calcium by neutron activation analysis in normals and osteoporotic 
      populations: a discriminator of significant bone mass loss.
PG  - 637-45
AB  - This paper reports total body calcium by neutron activation (TBC) measurements in 
      94 normal individuals and 86 osteoporotic patients. The ability of TBC to 
      discriminate normal from osteoporotic females was evaluated with decision 
      analysis. Bone mineral content (BMC) by single-photon absorptiometry was also 
      measured. TBC was higher in males (range 826 to 1363 gm vs 537 to 1054 in 
      females) and correlated with height in all normals (r = 0.55 in males, 0.58 in 
      females; p less than 0.001). In females over age 55 there was a negative 
      correlation with age (r = -0.51, p less than 0.01). Thus, for normals an 
      algorithm was derived to allow comparison between measured TBC and that predicted 
      by sex, age, and height (TBCp). In the 28 normal females over age 55, the TBC was 
      764 +/- 115 gm vs. 616 +/- 90 in the osteoporotics (p less than 0.001). In 63 of 
      the osteoporotic females an estimated height, from tibial length, was used to 
      predict TBC. In normals the TBC/TBCp ratio was 1.00 +/- 0.12, whereas in 
      osteoporotic females it was 0.80 +/- 0.12 (p less than 0.001). A receiver 
      operating characteristic curve showed better discrimination of osteoporosis with 
      TBC/TBCp than with wrist BMC. By using Bayes' theorem, with a 25% prevalence of 
      osteoporosis (estimate for postmenopausal women), the posttest probability of 
      disease was 90% when the TBC/TBCp ratio was less than 0.84. We conclude that a 
      low TBC/TBCp ratio is very helpful in determining osteoporosis.
FAU - Ott, S M
AU  - Ott SM
FAU - Murano, R
AU  - Murano R
FAU - Lewellen, T K
AU  - Lewellen TK
FAU - Nelp, W B
AU  - Nelp WB
FAU - Chesnut, C M 3rd
AU  - Chesnut CM 3rd
LA  - eng
GR  - RR-37/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Lab Clin Med
JT  - The Journal of laboratory and clinical medicine
JID - 0375375
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Activation Analysis
MH  - Adult
MH  - Age Determination by Skeleton
MH  - Aged
MH  - *Aging
MH  - Body Height
MH  - Bone and Bones/*metabolism/physiopathology
MH  - Calcium/*analysis
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Osteoporosis/diagnosis/*metabolism/physiopathology
MH  - Tibia/anatomy & histology
EDAT- 1983/10/01 00:00
MHDA- 1983/10/01 00:01
CRDT- 1983/10/01 00:00
PHST- 1983/10/01 00:00 [pubmed]
PHST- 1983/10/01 00:01 [medline]
PHST- 1983/10/01 00:00 [entrez]
AID - 0022-2143(83)90121-X [pii]
PST - ppublish
SO  - J Lab Clin Med. 1983 Oct;102(4):637-45.