PMID- 6620060
OWN - NLM
STAT- MEDLINE
DCOM- 19831123
LR  - 20131121
IS  - 0277-2116 (Print)
IS  - 0277-2116 (Linking)
VI  - 2
IP  - 3
DP  - 1983
TI  - Breath hydrogen analysis: a review of the methodologies and clinical 
      applications.
PG  - 525-33
AB  - Hydrogen gas (H2) is a product of the fermentation of dietary carbohydrate (CHO) 
      by bacteria in the lumen of the gastrointestinal tract in man. Thus, H2 is 
      actually an exogenously produced gas, which either is passed as flatus, or 
      diffuses into the body and is exhaled. In the adult, a fairly constant fraction 
      is expired, providing a reliable indicator of total colonic H2 production. Breath 
      H2 analysis currently represents a useful clinical means of testing adults and 
      older children for the malabsorption of CHO. Noninvasive and easy procedures for 
      the collection of expired air have encouraged their increasingly widespread use 
      in pediatrics. Evidence to date suggests that breath H2 analysis may provide the 
      best available method for estimating semiquantitatively the degree of CHO 
      malabsorption. The association of the results of breath H2 analysis with other 
      clinical measures of CHO digestion and absorption is expected, but discrepancies 
      can also be anticipated based on the nature of this particular trace gas method. 
      The interpretation of the results of breath H2 analysis in neonates and young 
      infants remains especially problematic because of confounding variables which are 
      difficult to control and are measured infrequently.
FAU - Ostrander, C R
AU  - Ostrander CR
FAU - Cohen, R S
AU  - Cohen RS
FAU - Hopper, A O
AU  - Hopper AO
FAU - Shahin, S M
AU  - Shahin SM
FAU - Kerner, J A Jr
AU  - Kerner JA Jr
FAU - Johnson, J D
AU  - Johnson JD
FAU - Stevenson, D K
AU  - Stevenson DK
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Pediatr Gastroenterol Nutr
JT  - Journal of pediatric gastroenterology and nutrition
JID - 8211545
RN  - 7YNJ3PO35Z (Hydrogen)
SB  - IM
MH  - Adult
MH  - Breath Tests/*methods
MH  - Chromatography, Gas
MH  - Colon/metabolism/microbiology
MH  - Diarrhea, Infantile/diagnosis
MH  - Humans
MH  - Hydrogen/*analysis
MH  - Infant
MH  - Infant, Newborn
MH  - Intestinal Absorption
MH  - Lactose Intolerance/*diagnosis
EDAT- 1983/01/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1983/01/01 00:00
PHST- 1983/01/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1983/01/01 00:00 [entrez]
PST - ppublish
SO  - J Pediatr Gastroenterol Nutr. 1983;2(3):525-33.