PMID- 6627034
OWN - NLM
STAT- MEDLINE
DCOM- 19831217
LR  - 20190719
IS  - 0361-9230 (Print)
IS  - 0361-9230 (Linking)
VI  - 11
IP  - 1
DP  - 1983 Jul
TI  - A short duration GABAergic inhibition in identified neostriatal medium spiny 
      neurons: in vitro slice study.
PG  - 103-10
AB  - Inhibition in the neostriatum was investigated in rat in vitro slice preparation 
      using intracellular recording and labeling technique. The initial response 
      recorded following local stimulation is a monosynaptically activated EPSP. In 17% 
      of the neurons tested, IPSPs were observed following EPSPs evoked by local 
      stimulation. In paired shock experiments reduction of test EPSP amplitude or 
      action potentials occurred over interstimulus intervals (ISIs) of 3-38 msec. In 
      some neurons, a pulse injection of depolarizing current was used to trigger an 
      action potential which was in a paired shock, used to condition a test 
      monosynaptically induced EPSP. Test EPSPs were shunted over ISIs less than 45 
      msec. Paired shock performed on the slices perfused with the medium containing 
      GABA antagonists (e.g., bicuculline methiodide, picrotoxin, or penicillin-G) 
      resulted invariably in potentiation of test EPSPs. Inhibition in the neostriatum 
      in vitro is demonstrated as reduction in test amplitude in paired shock tests, by 
      the presence of IPSPs and by the shunting of EPSPs conditioned by an action 
      potential triggered by direct depolarization. Neurons exhibiting these forms of 
      inhibition were intracellularly labelled with HRP and identified as medium spiny 
      neurons. These results indicate that striatal GABAergic medium spiny neurons 
      which are known to have an extensive axon collateral plexus play in a role in a 
      short lasting inhibition observed in the striatum.
FAU - Lighthall, J W
AU  - Lighthall JW
FAU - Kitai, S T
AU  - Kitai ST
LA  - eng
GR  - NS 14866/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Brain Res Bull
JT  - Brain research bulletin
JID - 7605818
RN  - 124-87-8 (Picrotoxin)
RN  - 40709-69-1 (bicuculline methiodide)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - Q42T66VG0C (Penicillin G)
RN  - Y37615DVKC (Bicuculline)
SB  - IM
MH  - Animals
MH  - Bicuculline/analogs & derivatives/pharmacology
MH  - Corpus Striatum/drug effects/*physiology
MH  - Electric Stimulation
MH  - Evoked Potentials/drug effects
MH  - In Vitro Techniques
MH  - Membrane Potentials
MH  - Neurons/drug effects/*physiology
MH  - Penicillin G/pharmacology
MH  - Picrotoxin/pharmacology
MH  - Rats
MH  - Synapses/physiology
MH  - gamma-Aminobutyric Acid/*physiology
EDAT- 1983/07/01 00:00
MHDA- 1983/07/01 00:01
CRDT- 1983/07/01 00:00
PHST- 1983/07/01 00:00 [pubmed]
PHST- 1983/07/01 00:01 [medline]
PHST- 1983/07/01 00:00 [entrez]
AID - 0361-9230(83)90058-8 [pii]
AID - 10.1016/0361-9230(83)90058-8 [doi]
PST - ppublish
SO  - Brain Res Bull. 1983 Jul;11(1):103-10. doi: 10.1016/0361-9230(83)90058-8.