PMID- 6628541
OWN - NLM
STAT- MEDLINE
DCOM- 19831217
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 92
IP  - 3-4
DP  - 1983 Sep 2
TI  - Different antagonist potency of saralasin in acute and chronic 
      angiotensin-dependent hypertension.
PG  - 207-13
AB  - We investigated the antagonistic properties of saralasin in acute and chronic 
      angiotension II (ANG II)-dependent hypertension. Two models of experimental 
      hypertension were studied: (a) Rats acutely infused i.v. with ANG II to raise the 
      blood pressure (BP) by about 35 mmHg. (b) One-clip, two-kidney renal hypertensive 
      rats. In both experimental models increasing doses of saralasin were infused 
      i.v., and three parameters were evaluated at each dose level: (1) fall of BP, (2) 
      plasma concentration of saralasin, and (3) plasma concentration of ANG II. It was 
      found that saralasin led to a more pronounced fall of BP in malignant than in 
      benign renal hypertension. To reduce BP by about 20 mmHg, saralasin plasma 
      concentrations had to exceed those of ANG II about 2000-fold in renal 
      hypertension and about 7-fold in rats infused with ANG II. It is concluded that 
      saralasin antagonises ANG II more effectively in acute than in chronic 
      hypertension.
FAU - Mann, J F
AU  - Mann JF
FAU - Dietz, R
AU  - Dietz R
FAU - Ritz, E
AU  - Ritz E
FAU - Ganten, D
AU  - Ganten D
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Angiotensin Receptor Antagonists)
RN  - 0 (Receptors, Angiotensin)
RN  - 11128-99-7 (Angiotensin II)
RN  - H2AFV2HE66 (Saralasin)
SB  - IM
MH  - Acute Disease
MH  - Angiotensin II/*antagonists & inhibitors
MH  - Angiotensin Receptor Antagonists
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - Chronic Disease
MH  - Hypertension, Malignant/*metabolism
MH  - Hypertension, Renovascular/*metabolism
MH  - Male
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Angiotensin/physiology
MH  - Saralasin/*pharmacology
EDAT- 1983/09/02 00:00
MHDA- 1983/09/02 00:01
CRDT- 1983/09/02 00:00
PHST- 1983/09/02 00:00 [pubmed]
PHST- 1983/09/02 00:01 [medline]
PHST- 1983/09/02 00:00 [entrez]
AID - 0014-2999(83)90288-1 [pii]
AID - 10.1016/0014-2999(83)90288-1 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1983 Sep 2;92(3-4):207-13. doi: 10.1016/0014-2999(83)90288-1.