PMID- 6631482
OWN - NLM
STAT- MEDLINE
DCOM- 19831217
LR  - 20191101
IS  - 0270-6474 (Print)
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Linking)
VI  - 3
IP  - 11
DP  - 1983 Nov
TI  - Tetanus toxin: convulsant action on mouse spinal cord neurons in culture.
PG  - 2310-23
AB  - The effects of direct application of tetanus toxin on fetal mouse spinal cord 
      neurons in culture are described. Tetanus toxin produces increased excitation 
      characterized by paroxysmal depolarizing events (PDE). In contrast to the abrupt 
      onset of convulsant action produced by postsynaptic glycine antagonist 
      strychnine, the convulsant action of tetanus occurs after a dose-dependent latent 
      period. The onset of the convulsant action of tetanus toxin is paralleled by a 
      reduction in observed spontaneous inhibitory synaptic potentials. Excitatory 
      synaptic events can be identified as components of some tetanus-PDE. The toxin 
      does not alter postsynaptic responses to the inhibitory amino acids glycine and 
      gamma-aminobutyric acid. The latency and convulsant action of tetanus toxin are 
      consistent with an irreversible presynaptic membrane interaction that reduces 
      inhibitory transmission, a mechanism of action distinct from those of convulsants 
      that antagonize inhibitory transmitters at the postsynaptic membrane.
FAU - Bergey, G K
AU  - Bergey GK
FAU - MacDonald, R L
AU  - MacDonald RL
FAU - Habig, W H
AU  - Habig WH
FAU - Hardegree, M C
AU  - Hardegree MC
FAU - Nelson, P G
AU  - Nelson PG
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Convulsants)
RN  - 0 (Tetanus Toxin)
SB  - IM
MH  - Action Potentials
MH  - Animals
MH  - Biomechanical Phenomena
MH  - Cells, Cultured
MH  - Convulsants/*pharmacology
MH  - Mice/embryology
MH  - Neurons/*drug effects/metabolism
MH  - Spinal Cord/cytology/*drug effects/embryology/metabolism
MH  - Synapses/physiology
MH  - Tetanus Toxin/metabolism/*pharmacology
PMC - PMC6564628
EDAT- 1983/11/01 00:00
MHDA- 1983/11/01 00:01
PMCR- 1984/05/01
CRDT- 1983/11/01 00:00
PHST- 1983/11/01 00:00 [pubmed]
PHST- 1983/11/01 00:01 [medline]
PHST- 1983/11/01 00:00 [entrez]
PHST- 1984/05/01 00:00 [pmc-release]
AID - 10.1523/JNEUROSCI.03-11-02310.1983 [doi]
PST - ppublish
SO  - J Neurosci. 1983 Nov;3(11):2310-23. doi: 10.1523/JNEUROSCI.03-11-02310.1983.