PMID- 6633160
OWN - NLM
STAT- MEDLINE
DCOM- 19831217
LR  - 20190701
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 33
IP  - 17
DP  - 1983 Oct 24
TI  - Effects of taurine and a taurine antagonist on some respiratory and 
      cardiovascular parameters.
PG  - 1649-55
AB  - Respiratory performance, heart rate and blood pressure were studied in halothane 
      anesthetized rats after administration of taurine and the putative taurine 
      antagonist 6-aminomethyl-3-methyl-4H-1,2,4-benzothiadiazine-1, 1-dioxide 
      hydrochloride (TAG). Intracerebroventricular (i.c.v.) taurine depressed 
      ventilation due to decreased inspiratory neural drive and depression of 
      respiratory timing mechanisms. I.c.v. administration of 1-100 micrograms TAG 
      caused no changes in the respiratory and circulatory parameters studied except at 
      the highest dose interval where respiratory frequency and minute ventilation were 
      depressed. The respiratory depression induced by taurine (0.2 mg) or beta-alanine 
      (1 mg) was antagonized by administration of TAG (100 micrograms). However, TAG 
      did not antagonize the respiratory effects induced by i.c.v. glycine or 
      gamma-aminobutyric acid (GABA) in equipotent respiratory depressant doses. The 
      decline in inspiratory neural drive as well as in "respiratory timing" after 
      i.c.v. taurine was restituted toward control values by TAG. The hypotension and 
      bradycardia induced by taurine were also antagonized by TAG. It is concluded that 
      TAG seems to antagonize the depressant action of taurine and beta-alanine but not 
      of GABA and glycine on respiratory performance. TAG might also possess some 
      partial agonist activity in higher doses.
FAU - Wessberg, P
AU  - Wessberg P
FAU - Hedner, T
AU  - Hedner T
FAU - Hedner, J
AU  - Hedner J
FAU - Jonason, J
AU  - Jonason J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Benzothiadiazines)
RN  - 1EQV5MLY3D (Taurine)
RN  - 80938-51-8 (6-aminomethyl-3-methyl-4H-1,2,4-benzothiadiazine 1,1-dioxide)
SB  - IM
MH  - Animals
MH  - Benzothiadiazines/*pharmacology
MH  - Cardiovascular System/*drug effects
MH  - Male
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Respiration/*drug effects
MH  - Taurine/antagonists & inhibitors/*pharmacology
EDAT- 1983/10/24 00:00
MHDA- 1983/10/24 00:01
CRDT- 1983/10/24 00:00
PHST- 1983/10/24 00:00 [pubmed]
PHST- 1983/10/24 00:01 [medline]
PHST- 1983/10/24 00:00 [entrez]
AID - 0024-3205(83)90720-8 [pii]
AID - 10.1016/0024-3205(83)90720-8 [doi]
PST - ppublish
SO  - Life Sci. 1983 Oct 24;33(17):1649-55. doi: 10.1016/0024-3205(83)90720-8.