PMID- 6644615
OWN - NLM
STAT- MEDLINE
DCOM- 19840107
LR  - 20190511
IS  - 0022-3751 (Print)
IS  - 1469-7793 (Electronic)
IS  - 0022-3751 (Linking)
VI  - 343
DP  - 1983 Oct
TI  - Amplitude fluctuations in synaptic potentials evoked in cat spinal motoneurones 
      at identified group Ia synapses.
PG  - 135-45
AB  - Excitatory post-synaptic potentials (e.p.s.p.s) were evoked in spinal 
      motoneurones (of anaesthetized cats) by impulses in single group Ia axons. The 
      morphological details of the Ia axon-motoneurone connexion involved in generating 
      each e.p.s.p. were subsequently reconstructed, as described by Redman & Walmsley 
      (1983). The fluctuation pattern of the peak amplitude of each e.p.s.p. was 
      determined using a deconvolution method, taking into account the recording noise. 
      Four e.p.s.p.s were analysed. One did not fluctuate in amplitude; the others 
      fluctuated between discrete amplitudes which were separated by quantal 
      increments. The number of increments which must be added to produce the largest 
      peak amplitude of each e.p.s.p. was always less than, or equal to, the number of 
      synaptic boutons in the connexion at which the e.p.s.p. was generated. The 
      results are consistent with the hypothesis that transmission occurs in an 
      all-or-none manner at each synaptic bouton. Different boutons in the termination 
      of a Ia axon with a motoneurone have different probabilities of releasing 
      transmitter, and this probability is sometimes zero at low stimulation rates. The 
      results support the idea that the discrete amplitudes of an evoked e.p.s.p. 
      result from intermittent transmission, in an all-or-none manner, at some or all 
      of the boutons in the termination.
FAU - Redman, S
AU  - Redman S
FAU - Walmsley, B
AU  - Walmsley B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Physiol
JT  - The Journal of physiology
JID - 0266262
SB  - IM
MH  - Animals
MH  - Axons/physiology
MH  - Cats
MH  - Dendrites/physiology
MH  - *Evoked Potentials
MH  - Motor Neurons/*physiology
MH  - Spinal Nerves/physiology
MH  - Synapses/*physiology/ultrastructure
MH  - Time Factors
PMC - PMC1193912
EDAT- 1983/10/01 00:00
MHDA- 1983/10/01 00:01
PMCR- 1983/10/01
CRDT- 1983/10/01 00:00
PHST- 1983/10/01 00:00 [pubmed]
PHST- 1983/10/01 00:01 [medline]
PHST- 1983/10/01 00:00 [entrez]
PHST- 1983/10/01 00:00 [pmc-release]
AID - 10.1113/jphysiol.1983.sp014885 [doi]
PST - ppublish
SO  - J Physiol. 1983 Oct;343:135-45. doi: 10.1113/jphysiol.1983.sp014885.