PMID- 6645209
OWN - NLM
STAT- MEDLINE
DCOM- 19840127
LR  - 20190725
IS  - 0085-2538 (Print)
IS  - 0085-2538 (Linking)
VI  - 24
IP  - 3
DP  - 1983 Sep
TI  - Renal calcium handling in familial hypocalciuric hypercalcemia.
PG  - 353-7
AB  - We have determined calcium and sodium excretion rates in three members of a 
      kinship with familial hypocalciuric hypercalcemia (FHH) and in four patients with 
      primary hyperparathyroidism (PHP) under control conditions and following the 
      intravenous administration of chlorothiazide or furosemide. The characteristic 
      hypocalciuria of FHH, evidenced by a significantly reduced urinary 
      calcium/creatinine ratio compared with that of PHP, is present under control 
      conditions (0.08 vs. 0.26 mg calcium/mg creatinine, respectively, P less than 
      0.05), and after chlorothiazide (0.14 vs. 0.53, respectively, P less than 0.01). 
      However, after furosemide infusion the calcium/creatinine ratio is no longer 
      lower in FHH than in PHP (1.12 vs. 1.14, respectively, P greater than 0.05). 
      These data suggest that, in FHH, tubular calcium reabsorption is enhanced in the 
      thick ascending limb of Henle's loop, the site of action of furosemide. However, 
      the data do not exclude the presence of an abnormality at a more distal site in 
      the nephron.
FAU - Watanabe, H
AU  - Watanabe H
FAU - Sutton, R A
AU  - Sutton RA
LA  - eng
PT  - Clinical Trial
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Kidney Int
JT  - Kidney international
JID - 0323470
RN  - 77W477J15H (Chlorothiazide)
RN  - 7LXU5N7ZO5 (Furosemide)
RN  - 9NEZ333N27 (Sodium)
RN  - AYI8EX34EU (Creatinine)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Calcium/*urine
MH  - Chlorothiazide/pharmacology
MH  - Creatinine/urine
MH  - Female
MH  - Furosemide/pharmacology
MH  - Humans
MH  - Hypercalcemia/genetics/physiopathology/*urine
MH  - Hyperparathyroidism/urine
MH  - Kidney/*physiopathology
MH  - Middle Aged
MH  - Sodium/urine
EDAT- 1983/09/01 00:00
MHDA- 1983/09/01 00:01
CRDT- 1983/09/01 00:00
PHST- 1983/09/01 00:00 [pubmed]
PHST- 1983/09/01 00:01 [medline]
PHST- 1983/09/01 00:00 [entrez]
AID - S0085-2538(15)33036-2 [pii]
AID - 10.1038/ki.1983.166 [doi]
PST - ppublish
SO  - Kidney Int. 1983 Sep;24(3):353-7. doi: 10.1038/ki.1983.166.