PMID- 6645498
OWN - NLM
STAT- MEDLINE
DCOM- 19840107
LR  - 20190817
IS  - 0022-4731 (Print)
IS  - 0022-4731 (Linking)
VI  - 19
IP  - 5
DP  - 1983 Nov
TI  - Endometrial tissue and plasma concentrations of 5-androstene-3 beta, 17 beta-diol 
      during the menstrual cycle in normal premenopausal and perimenopausal women.
PG  - 1627-34
AB  - A radioimmunoassay for 5-androstene-3 beta, 17 beta-diol (ADIOL) in human 
      endometrium and plasma is described. The recognised criteria of reliability have 
      been fulfilled. Plasma and endometrial tissue concentrations of ADIOL were 
      determined in samples obtained from normal premenopausal and perimenopausal women 
      (average ages 37 and 48 years respectively) at different phases of the menstrual 
      cycle. In perimenopausal women plasma concentrations of ADIOL did not vary 
      throughout the cycle (proliferative phase: 411 +/- 95 (SEM) pg/ml; secretory 
      phase: 462 +/- 28.5 (SEM) pg/ml). For the premenopausal group the pattern was 
      similar (proliferative phase: 568.4 +/- 56.9 (SEM) pg/ml; secretory phase: 663.1 
      +/- 64.7 (SEM) pg/ml) although a significant difference (P less than 0.05) was 
      noted between late proliferative and late secretory phase levels in these women. 
      A different pattern was observed for endometrial tissue concentrations of ADIOL. 
      In both groups of women a significant (3-4-fold) increase occurred during the 
      secretory phase. There was no apparent relationship between plasma and tissue 
      concentrations of ADIOL either during the proliferative or the secretory phase. 
      There was, however, an age associated decrease for both tissue and plasma ADIOL. 
      Theories are proposed to account for the increase in ADIOL concentration during 
      the luteal phase.
FAU - Bonney, R C
AU  - Bonney RC
FAU - Scanlon, M J
AU  - Scanlon MJ
FAU - Reed, M J
AU  - Reed MJ
FAU - James, V H
AU  - James VH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Steroid Biochem
JT  - Journal of steroid biochemistry
JID - 0260125
RN  - 0 (Androstenediols)
RN  - 95PS51EMXY (Androstenediol)
SB  - IM
MH  - Adult
MH  - Androstenediol/blood/*metabolism
MH  - Androstenediols/*metabolism
MH  - Cross Reactions
MH  - Endometrium/physiology
MH  - Female
MH  - Humans
MH  - *Menopause
MH  - *Menstruation
MH  - Middle Aged
MH  - Radioimmunoassay/methods
EDAT- 1983/11/01 00:00
MHDA- 1983/11/01 00:01
CRDT- 1983/11/01 00:00
PHST- 1983/11/01 00:00 [pubmed]
PHST- 1983/11/01 00:01 [medline]
PHST- 1983/11/01 00:00 [entrez]
AID - 10.1016/0022-4731(83)90381-3 [doi]
PST - ppublish
SO  - J Steroid Biochem. 1983 Nov;19(5):1627-34. doi: 10.1016/0022-4731(83)90381-3.