PMID- 6656288
OWN - NLM
STAT- MEDLINE
DCOM- 19840224
LR  - 20190725
IS  - 0022-5193 (Print)
IS  - 0022-5193 (Linking)
VI  - 105
IP  - 3
DP  - 1983 Dec 7
TI  - A model for the three-dimensional structure of glucagon.
PG  - 403-25
AB  - A literature search on the structural aspects of glucagon in dilute aqueous 
      solution has been undertaken. We have found that a compact, well-defined 
      structure must exist and propose a model for that structure. In doing so, care 
      was taken to distinguish between the raw data themselves and the interpretations 
      drawn from them, and to bring about a model consistent with as much of the data 
      as possible. The model building was performed on Corey-Pauling-Koltun (CPK) 
      space-filling models using secondary structure prediction rules, experimental 
      data such as fluorescence quenching, circular dichroism, NMR and high resolution 
      dark field electron microscopy, and was guided by a hierarchy of intramolecular 
      interactions which places hydrophobic bonding first and hydrogen bonding second. 
      This last criterion places a strict requirement on the model-building to maximize 
      contacts among complementary hydrophobic surfaces; this means that no empty 
      spaces are allowed inside the folded molecule. The resultant model is consistent 
      with all the relevant data. Furthermore, as demanded by any structure building 
      exercise, the model suggests structure-function relationships. One of the 
      predictions drawn from the structure--the binding of guanosine-5'-triphosphate 
      (GTP)--has been confirmed by a preliminary experiment (reported elsewhere). 
      Another aspect of the structure suggests a subtle mechanism for allostery.
FAU - Korn, A P
AU  - Korn AP
FAU - Ottensmeyer, F P
AU  - Ottensmeyer FP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Theor Biol
JT  - Journal of theoretical biology
JID - 0376342
RN  - 86-01-1 (Guanosine Triphosphate)
RN  - 9007-92-5 (Glucagon)
SB  - IM
MH  - *Glucagon
MH  - Guanosine Triphosphate
MH  - Hydrogen Bonding
MH  - *Models, Molecular
MH  - Molecular Conformation
EDAT- 1983/12/07 00:00
MHDA- 1983/12/07 00:01
CRDT- 1983/12/07 00:00
PHST- 1983/12/07 00:00 [pubmed]
PHST- 1983/12/07 00:01 [medline]
PHST- 1983/12/07 00:00 [entrez]
AID - 0022-5193(83)90184-4 [pii]
AID - 10.1016/0022-5193(83)90184-4 [doi]
PST - ppublish
SO  - J Theor Biol. 1983 Dec 7;105(3):403-25. doi: 10.1016/0022-5193(83)90184-4.